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Austrian syndrome, ceftriaxone-induced agranulocytosis and COVID-19.
McCulloch, James Edward; Miller, Alexandra; Borcea, Marius; Reid, Jeremy.
  • McCulloch JE; Intensive Care, Yeovil District Hospital NHS Foundation Trust, Yeovil, UK james_mcculloch@hotmail.com.
  • Miller A; Intensive Care, Yeovil District Hospital NHS Foundation Trust, Yeovil, UK.
  • Borcea M; Intensive Care Medicine, Yeovil District Hospital NHS Foundation Trust, Yeovil, UK.
  • Reid J; Anaesthesia, Yeovil District Hospital, Yeovil, UK.
BMJ Case Rep ; 14(1)2021 Jan 06.
Article in English | MEDLINE | ID: covidwho-1013027
ABSTRACT
We present a case of a 75-year-old woman with Austrian syndrome pneumonia, meningitis and endocarditis all due to Streptococcus pneumoniae Transoesophageal echocardiogram demonstrated a large mitral valve vegetation with severe mitral regurgitation. She was treated with intravenous ceftriaxone and listed for surgical repair of her mitral valve. Preoperatively, she developed an idiosyncratic drug-induced agranulocytosis secondary to ceftriaxone, which resolved on cessation of the medication. However, while awaiting neutrophil recovery, she developed an acute deterioration, becoming critically unwell. This deterioration was multifactorial, with acute decompensated heart failure alongside COVID-19. After multidisciplinary discussion, she was considered too unwell for surgery and palliated.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumococcal Infections / Ceftriaxone / Meningitis, Bacterial / Agranulocytosis / Endocarditis, Bacterial / SARS-CoV-2 / COVID-19 Type of study: Case report / Diagnostic study / Observational study Limits: Aged / Female / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Bcr-2020-239355

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumococcal Infections / Ceftriaxone / Meningitis, Bacterial / Agranulocytosis / Endocarditis, Bacterial / SARS-CoV-2 / COVID-19 Type of study: Case report / Diagnostic study / Observational study Limits: Aged / Female / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Bcr-2020-239355