Your browser doesn't support javascript.
An in silico screening on piper nigrum, syzygium aromaticum and zingiber officinale roscoe derived compounds against sars‐cov‐2: A drug repurposing approach
Biointerface Research in Applied Chemistry ; 11(4):11122-11134, 2021.
Article in English | Scopus | ID: covidwho-1013644
ABSTRACT
As of now, Coronavirus (COVID-19) is spreading overall quickly, and its control is troublesome because there is no compelling immunization or medications accessible in the medical sector. This contagious disease has been associated with numerous respiratory issues. Thus, there is a crucial need to elucidate plant-derived compounds that display inhibitory potential against potential targets of coronavirus and boost the human body's immunity. This infection can contaminate the individuals and cause diseases of the respiratory lot. This research has focused on exploiting the medicinal properties of phytocompounds of three plants that have shown significant anti-inflammatory potential and had been effective against numerous respiratory disorders. This research's main objective was to study the inhibitory potential of these selected twenty-seven phytocompounds derived from Piper nigrum, Syzygium aromaticum, and Zingiber officinale roscoe against protease of COVID-19. We performed screening of selected phytocompounds with antivirus action by employing different in silico approaches, including Lipinski rule of five, adme analysis, and molecular docking tools. In silico investigation has revealed the inhibitory potential of these selected ligands (phytocompounds), two crucial targets of coronavirus, including 6LU7 and 7JTL. Out of 27 selected phytocompounds guaiol and gingeronone A has displayed significant inhibitory potential against coronavirus's selected targets. Thus our research findings strongly recommended that phytocompounds derived from black pepper, clove, and ginger could be very useful in battling the COVID-19 pandemic era. © 2020 by the authors.

Full text: Available Collection: Databases of international organizations Database: Scopus Language: English Journal: Biointerface Research in Applied Chemistry Year: 2021 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: Databases of international organizations Database: Scopus Language: English Journal: Biointerface Research in Applied Chemistry Year: 2021 Document Type: Article