Analytical sensitivity and clinical sensitivity of the three rapid antigen detection kits for detection of SARS-CoV-2 virus.
J Clin Virol
; 133: 104684, 2020 12.
Article
in English
| MEDLINE | ID: covidwho-1014610
ABSTRACT
BACKGROUND:
Numerous rapid antigen detection (RAD) kits for diagnosing COVID-19 patients are available in the market recently.OBJECTIVE:
To compare analytical sensitivity and clinical sensitivity for the three commercially available RAD kits. STUDYDESIGN:
Analytical sensitivity for the detection of SARS-CoV-2 virus was determined by limit of detection (LOD) using RT-PCR as a reference method. Clinical sensitivity was evaluated by using respiratory specimens collected from confirmed COVID-19 patients.RESULTS:
The LOD results showed that the three RAD kits varied from 102-105 fold less sensitive than RT-PCR. Clinical sensitivity of RAD kits ranged from 22.9 %-71.4 % for detecting specimens from COVID-19 patients.CONCLUSIONS:
Although RAD kits were less sensitive than RT-PCR, understanding the clinical characteristics of different RAD kits can guide us to obtain suitable specimens for testing. The likelihood of positive results for RAD kits will be higher.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Nasopharynx
/
COVID-19 Serological Testing
/
COVID-19
/
Antigens, Viral
Type of study:
Diagnostic study
/
Experimental Studies
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
J Clin Virol
Journal subject:
Virology
Year:
2020
Document Type:
Article
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