Hepatic Injury in Patients With COVID-19.
J Clin Gastroenterol
; 54(10): 841-849, 2020.
Article
in English
| MEDLINE | ID: covidwho-1015407
ABSTRACT
BACKGROUND:
Coronavirus disease 2019 (COVID-19) has infected over 2 million people worldwide over the course of just several months. Various studies have highlighted that patients infected with COVID-19 may develop various degrees of liver injury. Here, we discuss the impact of underlying liver disease and manifestations of hepatic injury with COVID-19. We also review mechanisms of hepatic injury.METHODS:
We searched the database PubMed for all studies focused on hepatic injury in COVID-19.RESULTS:
We identified 13 studies that assessed the impact of underlying liver disease in patients infected with COVID-19 (N=3046). Underlying liver disease was one of the most common known comorbid categories in patients infected with COVID-19. Overall, 25% of the patients identified from the 13 studies had hepatic injury. Twenty-one percent and 24% had elevated alanine transaminase and aspartate transaminase values, respectively. Nine percent of the patients had elevated total bilirubin values. Ten of the 13 studies assessed COVID-19 acuity with severity of hepatic injury. In 9 of the 10 studies, clinical outcomes were worse with hepatic injury.CONCLUSIONS:
Liver injury is highly prevalent in patients that present with COVID-19. Since the liver is one of the most affected organs outside of the respiratory system in COVID-19, more intensive surveillance is warranted for severe cases, particularly among those with pre-existing advanced liver disease.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Aspartate Aminotransferases
/
Coronavirus Infections
/
Hepatic Insufficiency
/
Alanine Transaminase
/
Pandemics
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Reviews
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
J Clin Gastroenterol
Year:
2020
Document Type:
Article
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