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Hepatic Injury in Patients With COVID-19.
Kullar, Ravina; Patel, Ankur P; Saab, Sammy.
  • Kullar R; Expert Stewardship Inc., Newport Beach.
  • Patel AP; David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, CA.
  • Saab S; Expert Stewardship Inc., Newport Beach.
J Clin Gastroenterol ; 54(10): 841-849, 2020.
Article in English | MEDLINE | ID: covidwho-1015407
ABSTRACT

BACKGROUND:

Coronavirus disease 2019 (COVID-19) has infected over 2 million people worldwide over the course of just several months. Various studies have highlighted that patients infected with COVID-19 may develop various degrees of liver injury. Here, we discuss the impact of underlying liver disease and manifestations of hepatic injury with COVID-19. We also review mechanisms of hepatic injury.

METHODS:

We searched the database PubMed for all studies focused on hepatic injury in COVID-19.

RESULTS:

We identified 13 studies that assessed the impact of underlying liver disease in patients infected with COVID-19 (N=3046). Underlying liver disease was one of the most common known comorbid categories in patients infected with COVID-19. Overall, 25% of the patients identified from the 13 studies had hepatic injury. Twenty-one percent and 24% had elevated alanine transaminase and aspartate transaminase values, respectively. Nine percent of the patients had elevated total bilirubin values. Ten of the 13 studies assessed COVID-19 acuity with severity of hepatic injury. In 9 of the 10 studies, clinical outcomes were worse with hepatic injury.

CONCLUSIONS:

Liver injury is highly prevalent in patients that present with COVID-19. Since the liver is one of the most affected organs outside of the respiratory system in COVID-19, more intensive surveillance is warranted for severe cases, particularly among those with pre-existing advanced liver disease.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Aspartate Aminotransferases / Coronavirus Infections / Hepatic Insufficiency / Alanine Transaminase / Pandemics Type of study: Diagnostic study / Observational study / Prognostic study / Reviews Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: J Clin Gastroenterol Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Aspartate Aminotransferases / Coronavirus Infections / Hepatic Insufficiency / Alanine Transaminase / Pandemics Type of study: Diagnostic study / Observational study / Prognostic study / Reviews Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: J Clin Gastroenterol Year: 2020 Document Type: Article