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COVID-19: Neuroimaging Features of a Pandemic.
Ladopoulos, Theodoros; Zand, Ramin; Shahjouei, Shima; Chang, Jason J; Motte, Jeremias; Charles James, Jeyanthan; Katsanos, Aristeidis H; Kerro, Ali; Farahmand, Ghasem; Vaghefi Far, Alaleh; Rahimian, Nasrin; Ebrahimzadeh, Seyed Amir; Abedi, Vida; Papathanasiou, Matilda; Labedi, Adnan; Schneider, Ruth; Lukas, Carsten; Tsiodras, Sotirios; Tsivgoulis, Georgios; Krogias, Christos.
  • Ladopoulos T; Department of Neurology, St. Josef-Hospital Bochum, Ruhr University Bochum, Bochum, Germany.
  • Zand R; Department of Neurology, Geisinger Medical Center, Danville, PA.
  • Shahjouei S; Department of Neurology, Geisinger Medical Center, Danville, PA.
  • Chang JJ; Department of Critical Care Medicine, MedStar Washington Hospital Center, Washington, DC.
  • Motte J; Department of Neurology, Georgetown University Medical Center, Washington, DC.
  • Charles James J; Department of Neurology, St. Josef-Hospital Bochum, Ruhr University Bochum, Bochum, Germany.
  • Katsanos AH; Department of Neurology, St. Josef-Hospital Bochum, Ruhr University Bochum, Bochum, Germany.
  • Kerro A; Division of Neurology, McMaster University/Population Health Research Institute, Hamilton, ON, Canada.
  • Farahmand G; SCL Health Neuroscience Department, Billings, MT.
  • Vaghefi Far A; Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Rahimian N; Neurology Department, Tehran University of Medical Sciences, Tehran, Iran.
  • Ebrahimzadeh SA; Department of Neurology, Yasrebi Hospital, Kashan, Iran.
  • Abedi V; Department of Radiology, Yasrebi Hospital, Kashan, Iran.
  • Papathanasiou M; Department of Molecular and Functional Genomics, Weis Center for Research, Geisinger Health System, Danville, PA.
  • Labedi A; Second Department of Radiology, University of Athens, School of Medicine, "Attikon" University Hospital, Athens, Greece.
  • Schneider R; Department of Neurology, St. Josef-Hospital Bochum, Ruhr University Bochum, Bochum, Germany.
  • Lukas C; Department of Neurology, St. Josef-Hospital Bochum, Ruhr University Bochum, Bochum, Germany.
  • Tsiodras S; Institute of Neuroradiology, St. Josef-Hospital Bochum, Ruhr University Bochum, Bochum, Germany.
  • Tsivgoulis G; Fourth Department of Internal Medicine, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
  • Krogias C; Second Department of Neurology, "Attikon" University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
J Neuroimaging ; 31(2): 228-243, 2021 03.
Article in English | MEDLINE | ID: covidwho-1015550
Semantic information from SemMedBD (by NLM)
1. Disease COEXISTS_WITH COVID-19
Subject
Disease
Predicate
COEXISTS_WITH
Object
COVID-19
2. COVID-19 COEXISTS_WITH Cerebrovascular Disorders
Subject
COVID-19
Predicate
COEXISTS_WITH
Object
Cerebrovascular Disorders
3. COVID-19 COEXISTS_WITH Inflammatory Response
Subject
COVID-19
Predicate
COEXISTS_WITH
Object
Inflammatory Response
4. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
5. Neurologic Manifestations PROCESS_OF Patients
Subject
Neurologic Manifestations
Predicate
PROCESS_OF
Object
Patients
6. Ischemic stroke PROCESS_OF Patients
Subject
Ischemic stroke
Predicate
PROCESS_OF
Object
Patients
7. Hypertensive disease NEG_COEXISTS_WITH Hemorrhage
Subject
Hypertensive disease
Predicate
NEG_COEXISTS_WITH
Object
Hemorrhage
8. Hemorrhage PROCESS_OF Patients
Subject
Hemorrhage
Predicate
PROCESS_OF
Object
Patients
9. Cerebral Hemorrhage PROCESS_OF Patients
Subject
Cerebral Hemorrhage
Predicate
PROCESS_OF
Object
Patients
10. Encephalitis PROCESS_OF Patients
Subject
Encephalitis
Predicate
PROCESS_OF
Object
Patients
11. Central Nervous System Involvement PROCESS_OF Patients
Subject
Central Nervous System Involvement
Predicate
PROCESS_OF
Object
Patients
12. Disease COEXISTS_WITH COVID-19
Subject
Disease
Predicate
COEXISTS_WITH
Object
COVID-19
13. COVID-19 COEXISTS_WITH Cerebrovascular Disorders
Subject
COVID-19
Predicate
COEXISTS_WITH
Object
Cerebrovascular Disorders
14. COVID-19 COEXISTS_WITH Inflammatory Response
Subject
COVID-19
Predicate
COEXISTS_WITH
Object
Inflammatory Response
15. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
16. Neurologic Manifestations PROCESS_OF Patients
Subject
Neurologic Manifestations
Predicate
PROCESS_OF
Object
Patients
17. Ischemic stroke PROCESS_OF Patients
Subject
Ischemic stroke
Predicate
PROCESS_OF
Object
Patients
18. Hypertensive disease NEG_COEXISTS_WITH Hemorrhage
Subject
Hypertensive disease
Predicate
NEG_COEXISTS_WITH
Object
Hemorrhage
19. Hemorrhage PROCESS_OF Patients
Subject
Hemorrhage
Predicate
PROCESS_OF
Object
Patients
20. Cerebral Hemorrhage PROCESS_OF Patients
Subject
Cerebral Hemorrhage
Predicate
PROCESS_OF
Object
Patients
21. Encephalitis PROCESS_OF Patients
Subject
Encephalitis
Predicate
PROCESS_OF
Object
Patients
22. Central Nervous System Involvement PROCESS_OF Patients
Subject
Central Nervous System Involvement
Predicate
PROCESS_OF
Object
Patients
ABSTRACT
BACKGROUND AND

PURPOSE:

The ongoing Coronavirus Disease 2019 (COVID-19) pandemic is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is occasionally associated with manifold diseases of the central nervous system (CNS). We sought to present the neuroimaging features of such CNS involvement. In addition, we sought to identify typical neuroimaging patterns that could indicate possible COVID-19-associated neurological manifestations.

METHODS:

In this systematic literature review, typical neuroimaging features of cerebrovascular diseases and inflammatory processes associated with COVID-19 were analyzed. Reports presenting individual patient data were included in further quantitative analysis with descriptive statistics.

RESULTS:

We identified 115 studies reporting a total of 954 COVID-19 patients with associated neurological manifestations and neuroimaging alterations. A total of 95 (82.6%) of the identified studies were single case reports or case series, whereas 660 (69.2%) of the reported cases included individual information and were thus included in descriptive statistical analysis. Ischemia with neuroimaging patterns of large vessel occlusion event was revealed in 59.9% of ischemic stroke patients, whereas 69.2% of patients with intracerebral hemorrhage exhibited bleeding in a location that was not associated with hypertension. Callosal and/or juxtacortical location was identified in 58.7% of cerebral microbleed positive images. Features of hemorrhagic necrotizing encephalitis were detected in 28.8% of patients with meningo-/encephalitis.

CONCLUSIONS:

Manifold CNS involvement is increasingly reported in COVID-19 patients. Typical and atypical neuroimaging features have been observed in some disease entities, so that familiarity with these imaging patterns appears reasonable and may assist clinicians in the differential diagnosis of COVID-19 CNS manifestations.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain / COVID-19 Type of study: Reviews Limits: Humans Language: English Journal: J Neuroimaging Journal subject: Diagnostic Imaging / Neurology Year: 2021 Document Type: Article Affiliation country: Jon.12819

Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain / COVID-19 Type of study: Reviews Limits: Humans Language: English Journal: J Neuroimaging Journal subject: Diagnostic Imaging / Neurology Year: 2021 Document Type: Article Affiliation country: Jon.12819