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Repurposing Nucleoside Analogs for Human Coronaviruses.
Zandi, Keivan; Amblard, Franck; Musall, Katie; Downs-Bowen, Jessica; Kleinbard, Ruby; Oo, Adrian; Cao, Dongdong; Liang, Bo; Russell, Olivia O; McBrayer, Tamara; Bassit, Leda; Kim, Baek; Schinazi, Raymond F.
  • Zandi K; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Amblard F; Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
  • Musall K; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Downs-Bowen J; Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
  • Kleinbard R; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Oo A; Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
  • Cao D; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Liang B; Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
  • Russell OO; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
  • McBrayer T; Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
  • Bassit L; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Kim B; Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
  • Schinazi RF; Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.
Antimicrob Agents Chemother ; 65(1)2020 12 16.
Article in English | MEDLINE | ID: covidwho-1015593
ABSTRACT
Coronavirus disease 2019 (COVID-19) is a serious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or CoV-2). Some reports claimed certain nucleoside analogs to be active against CoV-2 and thus needed confirmation. Here, we evaluated a panel of compounds and identified novel nucleoside analogs with antiviral activity against CoV-2 and HCoV-OC43 while ruling out others. Of significance, sofosbuvir demonstrated no antiviral effect against CoV-2, and its triphosphate did not inhibit CoV-2 RNA polymerase.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Drug Repositioning / SARS-CoV-2 / Nucleosides Type of study: Experimental Studies / Prognostic study Topics: Traditional medicine Limits: Animals / Humans Language: English Year: 2020 Document Type: Article Affiliation country: AAC.01652-20

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Drug Repositioning / SARS-CoV-2 / Nucleosides Type of study: Experimental Studies / Prognostic study Topics: Traditional medicine Limits: Animals / Humans Language: English Year: 2020 Document Type: Article Affiliation country: AAC.01652-20