COVID-19 and Respiratory System Disorders: Current Knowledge, Future Clinical and Translational Research Questions.

Brosnahan, Shari B; Jonkman, Annemijn H; Kugler, Matthias C; Munger, John S; Kaufman, David A

Brosnahan, Shari B; Jonkman, Annemijn H; Kugler, Matthias C; Munger, John S; Kaufman, David A.

Brosnahan SB; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, NYU School of Medicine (S.B.B., M.C.K., J.S.M., D.A.K.).
Jonkman AH; Keenan Centre for Biomedical Research, Critical Care Department, St. Michael's Hospital, Toronto, Canada (A.H.J.).
Kugler MC; Department of Intensive Care Medicine, Amsterdam UMC, location VUmc, Amsterdam, the Netherlands (A.H.J.).
Munger JS; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, NYU School of Medicine (S.B.B., M.C.K., J.S.M., D.A.K.).
Kaufman DA; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, NYU School of Medicine (S.B.B., M.C.K., J.S.M., D.A.K.).

Arterioscler Thromb Vasc Biol ; 40(11): 2586-2597, 2020 11.

Article in English | MEDLINE | ID: covidwho-1015731

ABSTRACT

ABSTRACT

The severe acute respiratory syndrome coronavirus-2 emerged as a serious human pathogen in late 2019, causing the disease coronavirus disease 2019 (COVID-19). The most common clinical presentation of severe COVID-19 is acute respiratory failure consistent with the acute respiratory distress syndrome. Airway, lung parenchymal, pulmonary vascular, and respiratory neuromuscular disorders all feature in COVID-19. This article reviews what is known about the effects of severe acute respiratory syndrome coronavirus-2 infection on different parts of the respiratory system, clues to understanding the underlying biology of respiratory disease, and highlights current and future translation and clinical research questions.

Subject(s)

Betacoronavirus/pathogenicity; Coronavirus Infections/virology; Lung/virology; Pneumonia, Viral/virology; Respiration; Respiratory Distress Syndrome/virology; Respiratory Insufficiency/virology; Translational Research, Biomedical; Animals; COVID-19; Coronavirus Infections/diagnosis; Coronavirus Infections/physiopathology; Coronavirus Infections/therapy; Host-Pathogen Interactions; Humans; Lung/physiopathology; Pandemics; Pneumonia, Viral/diagnosis; Pneumonia, Viral/physiopathology; Pneumonia, Viral/therapy; Prognosis; Pulmonary Embolism/physiopathology; Pulmonary Embolism/therapy; Pulmonary Embolism/virology; Respiration, Artificial; Respiratory Distress Syndrome/diagnosis; Respiratory Distress Syndrome/physiopathology; Respiratory Distress Syndrome/therapy; Respiratory Insufficiency/diagnosis; Respiratory Insufficiency/physiopathology; Respiratory Insufficiency/therapy; Risk Factors; SARS-CoV-2; Venous Thromboembolism/physiopathology; Venous Thromboembolism/therapy; Venous Thromboembolism/virology

Keywords

COVID-19; acute respiratory distress syndrome; diaphragm; infection; respiratory system; thromboembolism

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Respiration / Respiratory Distress Syndrome / Respiratory Insufficiency / Coronavirus Infections / Translational Research, Biomedical / Betacoronavirus / Lung Type of study: Diagnostic study / Prognostic study Topics: Long Covid Limits: Animals / Humans Language: English Journal: Arterioscler Thromb Vasc Biol Journal subject: Vascular Diseases Year: 2020 Document Type: Article

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