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An integrated in silico immuno-genetic analytical platform provides insights into COVID-19 serological and vaccine targets.
Ward, Daniel; Higgins, Matthew; Phelan, Jody E; Hibberd, Martin L; Campino, Susana; Clark, Taane G.
  • Ward D; Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK. Daniel.ward1@lshtm.ac.uk.
  • Higgins M; Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
  • Phelan JE; Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
  • Hibberd ML; Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
  • Campino S; Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
  • Clark TG; Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK. Taane.clark@lshtm.ac.uk.
Genome Med ; 13(1): 4, 2021 01 07.
Article in English | MEDLINE | ID: covidwho-1059849
Preprint
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ABSTRACT
During COVID-19, diagnostic serological tools and vaccines have been developed. To inform control activities in a post-vaccine surveillance setting, we have developed an online "immuno-analytics" resource that combines epitope, sequence, protein and SARS-CoV-2 mutation analysis. SARS-CoV-2 spike and nucleocapsid proteins are both vaccine and serological diagnostic targets. Using the tool, the nucleocapsid protein appears to be a sub-optimal target for use in serological platforms. Spike D614G (and nsp12 L314P) mutations were most frequent (> 86%), whilst spike A222V/L18F have recently increased. Also, Orf3a proteins may be a suitable target for serology. The tool can accessed from http//genomics.lshtm.ac.uk/immuno (online); https//github.com/dan-ward-bio/COVID-immunoanalytics (source code).
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 Type of study: Diagnostic study Topics: Vaccines Limits: Humans Language: English Journal: Genome Med Year: 2021 Document Type: Article Affiliation country: S13073-020-00822-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 Type of study: Diagnostic study Topics: Vaccines Limits: Humans Language: English Journal: Genome Med Year: 2021 Document Type: Article Affiliation country: S13073-020-00822-6