The antiviral activities of TRIM proteins.
Curr Opin Microbiol
; 59: 50-57, 2021 02.
Article
in English
| MEDLINE | ID: covidwho-1017019
ABSTRACT
Tripartite motif (TRIM) proteins are a highly versatile family of host-cell factors that play an integral role in the mammalian defense against pathogens. TRIM proteins regulate either transcription-dependent antiviral responses such as pro-inflammatory cytokine induction, or they modulate other important cell-intrinsic defense pathways like autophagy. Additionally, TRIM proteins exert direct antiviral activity whereby they antagonize specific viral components through diverse mechanisms. Here, we summarize the latest discoveries on the molecular mechanisms of antiviral TRIM proteins and also discuss current and future trends in this fast-evolving field.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Tripartite Motif Proteins
Limits:
Animals
/
Humans
Language:
English
Journal:
Curr Opin Microbiol
Journal subject:
Microbiology
Year:
2021
Document Type:
Article
Affiliation country:
J.mib.2020.07.005
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