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A large-scale transcriptional study reveals inhibition of COVID-19 related cytokine storm by traditional Chinese medicines.
Dai, Yifei; Qiang, Weijie; Gui, Yu; Tan, Xue; Pei, Tianli; Lin, Kequan; Cai, Siwei; Sun, Liang; Ning, Guochen; Wang, Jianxun; Guo, Hongyan; Sun, Yimin; Cheng, Jing; Xie, Lan; Lan, Xun; Wang, Dong.
  • Dai Y; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
  • Qiang W; Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.
  • Gui Y; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.
  • Tan X; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
  • Pei T; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
  • Lin K; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
  • Cai S; High Performance Computing Department, National Supercomputing Center in Shenzhen, Shenzhen 518055, China.
  • Sun L; Department of Electronic and Computer Engineering, College of Engineering, Drexel University, Philadelphia 19104, USA.
  • Ning G; Dongli District Jinqiao Street Community Health Service Center, Tianjin 300300, China.
  • Wang J; Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China.
  • Guo H; School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China.
  • Sun Y; National Engineering Research Center for Beijing Biochip Technology, Beijing 102206, China.
  • Cheng J; National Engineering Research Center for Beijing Biochip Technology, Beijing 102206, China.
  • Xie L; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
  • Lan X; National Engineering Research Center for Beijing Biochip Technology, Beijing 102206, China.
  • Wang D; State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing 100084, China.
Sci Bull (Beijing) ; 66(9): 884-888, 2021 May 15.
Article in English | MEDLINE | ID: covidwho-1019467
ABSTRACT
Coronavirus disease-2019 (COVID-19) has become a major global epidemic. Facilitated by HTS2 technology, we evaluated the effects of 578 herbs and all 338 reported anti-COVID-19 TCM formulae on cytokine storm-related signaling pathways, and identified the key targets of the relevant pathways and potential active ingredients in these herbs. This large-scale transcriptional study innovatively combines HTS2 technology with bioinformatics methods and computer-aided drug design. For the first time, it systematically explores the molecular mechanism of TCM in regulating the COVID-19-related cytokine storm, providing an important scientific basis for elucidating the mechanism of action of TCM in treating COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Topics: Traditional medicine Language: English Journal: Sci Bull (Beijing) Year: 2021 Document Type: Article Affiliation country: J.scib.2021.01.005

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Topics: Traditional medicine Language: English Journal: Sci Bull (Beijing) Year: 2021 Document Type: Article Affiliation country: J.scib.2021.01.005