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Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area.
Richardson, Safiya; Hirsch, Jamie S; Narasimhan, Mangala; Crawford, James M; McGinn, Thomas; Davidson, Karina W; Barnaby, Douglas P; Becker, Lance B; Chelico, John D; Cohen, Stuart L; Cookingham, Jennifer; Coppa, Kevin; Diefenbach, Michael A; Dominello, Andrew J; Duer-Hefele, Joan; Falzon, Louise; Gitlin, Jordan; Hajizadeh, Negin; Harvin, Tiffany G; Hirschwerk, David A; Kim, Eun Ji; Kozel, Zachary M; Marrast, Lyndonna M; Mogavero, Jazmin N; Osorio, Gabrielle A; Qiu, Michael; Zanos, Theodoros P.
  • Richardson S; Institute of Health Innovations and Outcomes Research, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.
  • Hirsch JS; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.
  • Narasimhan M; Institute of Health Innovations and Outcomes Research, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.
  • Crawford JM; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.
  • McGinn T; Department of Information Services, Northwell Health, New Hyde Park, New York.
  • Davidson KW; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.
  • Barnaby DP; Institute of Health Innovations and Outcomes Research, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.
  • Becker LB; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.
  • Chelico JD; Institute of Health Innovations and Outcomes Research, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.
  • Cohen SL; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.
  • Coppa K; Institute of Health Innovations and Outcomes Research, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.
  • Diefenbach MA; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.
  • Dominello AJ; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.
  • Duer-Hefele J; Institute of Health Innovations and Outcomes Research, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.
  • Falzon L; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.
  • Gitlin J; Institute of Health Innovations and Outcomes Research, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.
  • Hajizadeh N; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.
  • Harvin TG; Institute of Health Innovations and Outcomes Research, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.
  • Hirschwerk DA; Department of Information Services, Northwell Health, New Hyde Park, New York.
  • Kim EJ; Institute of Health Innovations and Outcomes Research, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.
  • Kozel ZM; Institute of Health Innovations and Outcomes Research, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.
  • Marrast LM; Institute of Health Innovations and Outcomes Research, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.
  • Mogavero JN; Institute of Health Innovations and Outcomes Research, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.
  • Osorio GA; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.
  • Qiu M; Institute of Health Innovations and Outcomes Research, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.
  • Zanos TP; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.
JAMA ; 323(20): 2052-2059, 2020 05 26.
Article in English | MEDLINE | ID: covidwho-101977
Semantic information from SemMedBD (by NLM)
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2. Hospitalization TREATS COVID-19
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3. COVID-19 PROCESS_OF Patients
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COVID-19
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4. 2019 novel coronavirus PROCESS_OF Patients
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5. Invasive mechanical ventilation NOS ADMINISTERED_TO Patients
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6. COVID-19 PROCESS_OF hospitalized patients
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COVID-19
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7. Comorbidity PROCESS_OF Patients
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8. Hospitalization TREATS COVID-19
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9. COVID-19 PROCESS_OF Patients
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10. 2019 novel coronavirus PROCESS_OF Patients
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11. Invasive mechanical ventilation NOS ADMINISTERED_TO Patients
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ABSTRACT
Importance There is limited information describing the presenting characteristics and outcomes of US patients requiring hospitalization for coronavirus disease 2019 (COVID-19).

Objective:

To describe the clinical characteristics and outcomes of patients with COVID-19 hospitalized in a US health care system. Design, Setting, and

Participants:

Case series of patients with COVID-19 admitted to 12 hospitals in New York City, Long Island, and Westchester County, New York, within the Northwell Health system. The study included all sequentially hospitalized patients between March 1, 2020, and April 4, 2020, inclusive of these dates. Exposures Confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by positive result on polymerase chain reaction testing of a nasopharyngeal sample among patients requiring admission. Main Outcomes and

Measures:

Clinical outcomes during hospitalization, such as invasive mechanical ventilation, kidney replacement therapy, and death. Demographics, baseline comorbidities, presenting vital signs, and test results were also collected.

Results:

A total of 5700 patients were included (median age, 63 years [interquartile range {IQR}, 52-75; range, 0-107 years]; 39.7% female). The most common comorbidities were hypertension (3026; 56.6%), obesity (1737; 41.7%), and diabetes (1808; 33.8%). At triage, 30.7% of patients were febrile, 17.3% had a respiratory rate greater than 24 breaths/min, and 27.8% received supplemental oxygen. The rate of respiratory virus co-infection was 2.1%. Outcomes were assessed for 2634 patients who were discharged or had died at the study end point. During hospitalization, 373 patients (14.2%) (median age, 68 years [IQR, 56-78]; 33.5% female) were treated in the intensive care unit care, 320 (12.2%) received invasive mechanical ventilation, 81 (3.2%) were treated with kidney replacement therapy, and 553 (21%) died. As of April 4, 2020, for patients requiring mechanical ventilation (n = 1151, 20.2%), 38 (3.3%) were discharged alive, 282 (24.5%) died, and 831 (72.2%) remained in hospital. The median postdischarge follow-up time was 4.4 days (IQR, 2.2-9.3). A total of 45 patients (2.2%) were readmitted during the study period. The median time to readmission was 3 days (IQR, 1.0-4.5) for readmitted patients. Among the 3066 patients who remained hospitalized at the final study follow-up date (median age, 65 years [IQR, 54-75]), the median follow-up at time of censoring was 4.5 days (IQR, 2.4-8.1). Conclusions and Relevance This case series provides characteristics and early outcomes of sequentially hospitalized patients with confirmed COVID-19 in the New York City area.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Comorbidity / Coronavirus Infections / Betacoronavirus Type of study: Etiology study / Risk factors Topics: Long Covid Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Country/Region as subject: North America Language: English Journal: JAMA Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Comorbidity / Coronavirus Infections / Betacoronavirus Type of study: Etiology study / Risk factors Topics: Long Covid Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Country/Region as subject: North America Language: English Journal: JAMA Year: 2020 Document Type: Article