The powerful immune system against powerful COVID-19: A hypothesis.

Taghizadeh-Hesary, Farzad; Akbari, Hassan

Taghizadeh-Hesary, Farzad; Akbari, Hassan.

Taghizadeh-Hesary F; Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Akbari H; Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Med Hypotheses ; 140: 109762, 2020 Jul.

Article in English | MEDLINE | ID: covidwho-101985

ABSTRACT

ABSTRACT

On March 11, 2020, the World Health Organization declared the coronavirus outbreak a pandemic. Since December 2019, the world has experienced an outbreak of coronavirus disease 2019 (COVID-19). Epidemiology, risk factors, and clinical characteristics of patients with COVID-19 have been reported but the factors affecting the immune system against COVID-19 have not been well described. In this article, we provide a novel hypothesis to describe how an increase in cellular adenosine triphosphate (c-ATP) can potentially improve the efficiency of innate and adaptive immune systems to either prevent or fight off COVID-19.

Subject(s)

Adenosine Triphosphate/immunology; Coronavirus Infections/immunology; Immune System; Pneumonia, Viral/immunology; Aged; Apoptosis; Betacoronavirus; COVID-19; Comorbidity; Cytokines/immunology; Female; Humans; Interferons/immunology; Male; Models, Theoretical; Pandemics; Prognosis; SARS-CoV-2; Sex Factors; Smoking; T-Lymphocytes/immunology; Tobacco Use Disorder/complications

Keywords

ATP; COVID-19; Immune dysfunction

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Adenosine Triphosphate / Coronavirus Infections / Immune System Type of study: Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male Language: English Journal: Med Hypotheses Year: 2020 Document Type: Article Affiliation country: J.mehy.2020.109762

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