Factors associated with negative conversion of viral RNA in patients hospitalized with COVID-19.
Sci Total Environ
; 728: 138812, 2020 Aug 01.
Article
in English
| MEDLINE | ID: covidwho-102112
ABSTRACT
Factors associated with negative conversion of SARS-CoV-2 RNA in hospitalized patients have not yet been systematically determined. We conducted a retrospective cohort study of COVID-19 patients in Qingdao, China. Both univariate and multivariate analysis were performed to identify independent factors for time to viral RNA negative conversion. Data on patients with re-detectable viral RNA after showing negative on RT-PCR test (intermittent negative status) were also analyzed. A total of 59 patients confirmed with COVID-19 were included in this study, with a median duration of 1 (interquartile range, IQR 0-2) day from symptom onset to hospital admission. Median communicable period (from first day of positive nucleic acid test to first day of consecutive negative results) was 14 (IQR 10-18) days, and 7 (IQR 6-10) days for 10 patients with intermittent negative results. Age older than 45 years (hazard ratio, HR 0.378; 95% confidence interval, CI 0.205-0.698) and chest tightness (HR 0.290; 95%CI 0.091-0.919) were factors independently affecting negative conversion of SARS-CoV-2 RNA. Headache (odds ratio 7.553; 95%CI 1.011-28.253) was significantly associated with intermittent negative status, with a predicted probability of 60%. Older age and chest tightness were independently associated with delayed clearance of SARS-CoV-2 RNA in hospitalized patients. These predictors would provide a new perspective on early identification of patients with prolonged viral shedding and facilitate optimal isolation protocols and treatment strategies.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
RNA, Viral
/
Age Factors
/
Coronavirus Infections
Type of study:
Cohort study
/
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
English
Journal:
Sci Total Environ
Year:
2020
Document Type:
Article
Affiliation country:
J.scitotenv.2020.138812
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