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Mortality and Transfusion Requirements in COVID-19 Hospitalized Italian Patients According to Severity of the Disease.
Grandone, Elvira; Pesavento, Raffaele; Tiscia, Giovanni; De Laurenzo, Antonio; Ceccato, Davide; Sartori, Maria Teresa; Mirabella, Lucia; Cinnella, Gilda; Mastroianno, Mario; Dalfino, Lidia; Colaizzo, Donatella; Vettor, Roberto; Ostuni, Angelo; Margaglione, Maurizio.
  • Grandone E; Thrombosis and Haemostasis Unit, Fondazione I.R.C.C.S. "Casa Sollievo della Sofferenza", 71013 San Giovanni Rotondo, Italy.
  • Pesavento R; Ob/Gyn Department of the First I.M. Sechenov Moscow State Medical University, 119435 Moscow, Russia.
  • Tiscia G; Department of Internal Medicine, University of Padua, 35122 Padua, Italy.
  • De Laurenzo A; Thrombosis and Haemostasis Unit, Fondazione I.R.C.C.S. "Casa Sollievo della Sofferenza", 71013 San Giovanni Rotondo, Italy.
  • Ceccato D; Thrombosis and Haemostasis Unit, Fondazione I.R.C.C.S. "Casa Sollievo della Sofferenza", 71013 San Giovanni Rotondo, Italy.
  • Sartori MT; Department of Internal Medicine, University of Padua, 35122 Padua, Italy.
  • Mirabella L; Department of Internal Medicine, University of Padua, 35122 Padua, Italy.
  • Cinnella G; Department of Anesthesia and Intensive care, University of Foggia, 71122 Foggia, Italy.
  • Mastroianno M; Department of Anesthesia and Intensive care, University of Foggia, 71122 Foggia, Italy.
  • Dalfino L; Scientific Direction, Fondazione I.R.C.C.S. "Casa Sollievo della Sofferenza", 71013 San Giovanni Rotondo, Italy.
  • Colaizzo D; Anesthesia and Intensive care Unit, University of Bari, 70121 Bari, Italy.
  • Vettor R; Thrombosis and Haemostasis Unit, Fondazione I.R.C.C.S. "Casa Sollievo della Sofferenza", 71013 San Giovanni Rotondo, Italy.
  • Ostuni A; Department of Internal Medicine, University of Padua, 35122 Padua, Italy.
  • Margaglione M; Immunohematology and Transfusion Medicine Service, Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, University of Bari "Aldo Moro", 7012 Bari, Italy and Struttura Regionale Coordinamento, 70124 Bari, Italy.
J Clin Med ; 10(2)2021 Jan 11.
Article in English | MEDLINE | ID: covidwho-1021981
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. Patients LOCATION_OF IMPACT gene
Subject
Patients
Predicate
LOCATION_OF
Object
IMPACT gene
3. COVID-19 PROCESS_OF hospitalized patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
hospitalized patients
4. Chronic Kidney Diseases PROCESS_OF Patients
Subject
Chronic Kidney Diseases
Predicate
PROCESS_OF
Object
Patients
5. American College of Cardiology/American Heart Association Lesion Complexity Score C PROCESS_OF Patients
Subject
American College of Cardiology/American Heart Association Lesion Complexity Score C
Predicate
PROCESS_OF
Object
Patients
6. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
7. Patients LOCATION_OF IMPACT gene
Subject
Patients
Predicate
LOCATION_OF
Object
IMPACT gene
8. COVID-19 PROCESS_OF hospitalized patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
hospitalized patients
9. Chronic Kidney Diseases PROCESS_OF Patients
Subject
Chronic Kidney Diseases
Predicate
PROCESS_OF
Object
Patients
10. American College of Cardiology/American Heart Association Lesion Complexity Score C PROCESS_OF Patients
Subject
American College of Cardiology/American Heart Association Lesion Complexity Score C
Predicate
PROCESS_OF
Object
Patients
ABSTRACT
There is paucity of data on the transfusion need and its impact on the overall mortality in patients with COVID-19. We explored mortality in hospitalized patients with COVID-19 who required transfusions. Information on clinical variables and in-hospital mortality were obtained from medical records of 422 patients admitted to medical wards or the Intensive Care Unit (ICU). In-hospital mortality occurred in 147 (34.8%) patients, 94 (63.9%) of whom were admitted to the ICU. The median fatalities age was 77 years (IQR 14). Overall, 100 patients (60 males) received transfusion during hospitalization. The overall mortality was significantly and independently associated with age, ICU admission, Chronic Kidney Disease (CKD), and the number of transfused Red Blood Cell (RBC) units. Specifically, CKD was associated with mortality in patients admitted to medical wards, whereas the number of transfused RBC units predicted mortality in those admitted to the ICU. Transfusion strongly interacted with the admission to ICU (OR 9.9; 95% CI 2.5-40.0). In patients with COVID-19, age is one of the strongest risk factors in predicting mortality independently of the disease's severity. CKD confers a higher risk of mortality in patients admitted to medical wards. In those admitted to the ICU, the more RBC units are transfused, the more mortality increases.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study / Risk factors Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10020242

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study / Risk factors Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10020242