Lung adenocarcinoma patients have higher risk of SARS-CoV-2 infection.
Aging (Albany NY)
; 13(2): 1620-1632, 2021 01 10.
Article
in English
| MEDLINE | ID: covidwho-1022288
ABSTRACT
Both lung adenocarcinoma and coronavirus disease 2019 would cause pulmonary inflammation. Angiotensin-converting enzyme 2, the functional receptor of SARS-CoV-2, also plays a key role in lung adenocarcinoma. To study the risk of SARS-CoV-2 infection in lung adenocarcinoma patients, mRNA and microRNA profiles were obtained from The Cancer Genome Atlas and Gene Expression Omnibus followed by bioinformatics analysis. A network which regards angiotensin-converting enzyme 2 as the center was structured. In addition, via immunological analysis to explore the essential mechanism of SARS-CoV-2 susceptibility in lung adenocarcinoma. Compared with normal tissue, angiotensin-converting enzyme 2 was increased in lung adenocarcinoma patients. Furthermore, a total of 7 correlated differently expressed mRNAs (ACE2, CXCL9, MMP12, IL6, AZU1, FCN3, HYAL1 and IRAK3) and 5 correlated differently expressed microRNAs (miR-125b-5p, miR-9-5p, miR-130b-5p, miR-381-3p and miR-421) were screened. Interestingly, the most frequent toll-like receptor signaling pathway was enriched by mRNA (interlukin 6) and miRNA (miR-125b-5p) sets simultaneously. In conclusion, it was assumed that miR-125b-5p-ACE2-IL6 axis could alter the risk of SARS-CoV-2 infection in lung adenocarcinoma patients.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Transcriptome
/
Adenocarcinoma of Lung
/
Angiotensin-Converting Enzyme 2
/
COVID-19
/
Lung Neoplasms
Type of study:
Prognostic study
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Aging (Albany NY)
Journal subject:
Geriatrics
Year:
2021
Document Type:
Article
Affiliation country:
Aging.202375
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