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Shorter telomere lengths in patients with severe COVID-19 disease.
Sanchez-Vazquez, Raul; Guío-Carrión, Ana; Zapatero-Gaviria, Antonio; Martínez, Paula; Blasco, Maria A.
  • Sanchez-Vazquez R; Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Melchor Fernández Almagro 3, Madrid, Spain.
  • Guío-Carrión A; Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Melchor Fernández Almagro 3, Madrid, Spain.
  • Zapatero-Gaviria A; Field Hospital COVID-19, IFEMA, Madrid, Spain.
  • Martínez P; Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Melchor Fernández Almagro 3, Madrid, Spain.
  • Blasco MA; Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Melchor Fernández Almagro 3, Madrid, Spain.
Aging (Albany NY) ; 13(1): 1-15, 2021 01 11.
Article in English | MEDLINE | ID: covidwho-1068118
ABSTRACT
The incidence of severe manifestations of COVID-19 increases with age with older patients showing the highest mortality, suggesting that molecular pathways underlying aging contribute to the severity of COVID-19. One mechanism of aging is the progressive shortening of telomeres, which are protective structures at chromosome ends. Critically short telomeres impair the regenerative capacity of tissues and trigger loss of tissue homeostasis and disease. The SARS-CoV-2 virus infects many different cell types, forcing cell turn-over and regeneration to maintain tissue homeostasis. We hypothesize that presence of short telomeres in older patients limits the tissue response to SARS-CoV-2 infection. We measure telomere length in peripheral blood lymphocytes COVID-19 patients with ages between 29 and 85 years-old. We find that shorter telomeres are associated to increased severity of the disease. Individuals within the lower percentiles of telomere length and higher percentiles of short telomeres have higher risk of developing severe COVID-19 pathologies.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Aging / Telomere / Telomere Shortening / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Aging (Albany NY) Journal subject: Geriatrics Year: 2021 Document Type: Article Affiliation country: Aging.202463

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Aging / Telomere / Telomere Shortening / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Aging (Albany NY) Journal subject: Geriatrics Year: 2021 Document Type: Article Affiliation country: Aging.202463