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Occurrence of SARS-CoV-2 in the intraocular milieu.
List, Wolfgang; Regitnig, Peter; Kashofer, Karl; Gorkiewicz, Gregor; Zacharias, Martin; Wedrich, Andreas; Posch-Pertl, Laura.
  • List W; Department of Ophthalmology, Medical University of Graz Auenbruggerplatz 4, 8036, Graz, Austria. Electronic address: wolfgang.list@medunigraz.at.
  • Regitnig P; Diagnostic and Research Institute of Pathology, Medical University of Graz Neue Stiftingtalstraße 6, 8010, Graz, Austria.
  • Kashofer K; Diagnostic and Research Institute of Pathology, Medical University of Graz Neue Stiftingtalstraße 6, 8010, Graz, Austria.
  • Gorkiewicz G; Diagnostic and Research Institute of Pathology, Medical University of Graz Neue Stiftingtalstraße 6, 8010, Graz, Austria.
  • Zacharias M; Diagnostic and Research Institute of Pathology, Medical University of Graz Neue Stiftingtalstraße 6, 8010, Graz, Austria.
  • Wedrich A; Department of Ophthalmology, Medical University of Graz Auenbruggerplatz 4, 8036, Graz, Austria.
  • Posch-Pertl L; Department of Ophthalmology, Medical University of Graz Auenbruggerplatz 4, 8036, Graz, Austria.
Exp Eye Res ; 201: 108273, 2020 12.
Article in English | MEDLINE | ID: covidwho-1023565
ABSTRACT
The purpose of this research is to study the intraocular occurrence of SARS-CoV-2. In postmortem examinations, aqueous humor and the vitreous samples were collected. All individuals were previously positive in nasopharyngeal swabbing and cause of death was respiratory failure due to SARS-CoV-2 infection. Testing was done using quantitative RT-PCR. We included 16 aqueous humor and 16 vitreous samples for PCR testing. None of the results was positive for SARS-CoV-2. Human GAPDH genes to verify the presence of RNA was present in all aqueous humor samples (16/16, 100%) and 15/16 (93.8%) vitreous samples. In conclusion, this case series found no evidence of SARS-CoV-2 in the intraocular milieu.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Aqueous Humor / Vitreous Body / RNA, Viral / COVID-19 Testing / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Observational study Limits: Humans Language: English Journal: Exp Eye Res Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Aqueous Humor / Vitreous Body / RNA, Viral / COVID-19 Testing / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Observational study Limits: Humans Language: English Journal: Exp Eye Res Year: 2020 Document Type: Article