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Comparison of the SARS-CoV-2 (2019-nCoV) M protein with its counterparts of SARS-CoV and MERS-CoV species.
Alharbi, Sultan Nafea; Alrefaei, Abdulwahed Fahad.
  • Alharbi SN; National Centre for Biotechnology, King Abdulaziz City for Science and Technology, Riyadh 11442, Saudi Arabia.
  • Alrefaei AF; Department of Zoology, King Saud University, College of Science, P. O. Box 2455, Riyadh 11451, Saudi Arabia.
J King Saud Univ Sci ; 33(2): 101335, 2021 Mar.
Article in English | MEDLINE | ID: covidwho-1023655
ABSTRACT
Coronaviruses M proteins are well-represented in the major protein component of the viral envelope. During the viral assembly, they play an important role by association with all other viral structural proteins. Despite their crucial functions, very little information regarding the structures and functions of M proteins is available. Here we utilize bioinformatic tools from available sequences and 3D structures of SARS-CoV, SARS-CoV2, and MERS-CoV M proteins in order to predict potential B-cell epitopes and assessing antibody binding affinity. Such study aims to aid finding more effective vaccines and recognize neutralizing antibodies. we found some rather exciting differences between SARS-COV-2, SARS-Cov and MERS-CoV M proteins. Two SARS-CoV-2 peptides with significant antigen presentation scores for human cell surface proteins have been identified. The results reveal that N-terminal domains of M proteins of SARS-CoV and SARS-CoV2 are translocated (outside) whereas it is inside (cytoplasmic side) in MERS-CoV.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Vaccines Language: English Journal: J King Saud Univ Sci Year: 2021 Document Type: Article Affiliation country: J.jksus.2020.101335

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Vaccines Language: English Journal: J King Saud Univ Sci Year: 2021 Document Type: Article Affiliation country: J.jksus.2020.101335