EEG findings and clinical prognostic factors associated with mortality in a prospective cohort of inpatients with COVID-19.
Seizure
; 83: 1-4, 2020 Dec.
Article
in English
| MEDLINE | ID: covidwho-1023745
ABSTRACT
PURPOSE:
Our objective is to describe the most prevalent electroencephalographic findings in COVID-19 hospitalized patients, and to determine possible predictors of mortality including EEG and clinical variables.METHODS:
A multicentric prospective observational study in patients with COVID-19 requiring EEG during hospitalization.RESULTS:
We found 94 EEG from 62 patients (55 % men, mean age 59.7 ± 17.8 years) were analyzed. Most frequent comorbidity was cardiac (52 %), followed by metabolic (45 %) and CNS disease (39 %). Patients required ICU management by 60 %, with a mortality of 27 % in the whole cohort. The most frequent EEG finding was generalized continuous slow-wave activity (66 %). Epileptic activity was observed in 19 % including non-convulsive status epilepticus, seizures and interictal epileptiform discharges. Periodic patterns were observed in 3 patients (3.2 %). Multivariate analysis found that cancer comorbidity and requiring an EEG during the third week of evolution portended a higher risk of mortalityCONCLUSION:
We observed that the most prevalent EEG finding in this cohort was generalized continuous slow-wave activity, while epileptic activity was observed in less than 20 % of the cases. Mortality risk factors were comorbidity with cancer and requiring an EEG during the third week of evolution, possibly related to the hyperinflammatory state.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Seizures
/
Electroencephalography
/
SARS-CoV-2
/
COVID-19
Type of study:
Cohort study
/
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
Seizure
Journal subject:
Neurology
Year:
2020
Document Type:
Article
Affiliation country:
J.seizure.2020.10.007
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