Betacoronavirus; Coronavirus Infections/prevention & control; Pandemics/prevention & control; Pneumonia, Viral/prevention & control; Viral Vaccines; Animals; Betacoronavirus/genetics; Betacoronavirus/immunology; Biotechnology; COVID-19; COVID-19 Vaccines; Clinical Trials, Phase III as Topic; Coronavirus Infections/immunology; Coronavirus Infections/virology; Disease Models, Animal; Drug Development/methods; Drug Development/trends; Genetic Vectors; Global Health; Host Microbial Interactions/immunology; Humans; Immunity, Cellular; Immunity, Herd; Immunity, Humoral; Pneumonia, Viral/immunology; Pneumonia, Viral/virology; SARS-CoV-2; Safety; Spike Glycoprotein, Coronavirus/genetics; Spike Glycoprotein, Coronavirus/immunology; Translational Research, Biomedical; Vaccines, DNA/genetics; Vaccines, DNA/isolation & purification; Vaccines, Synthetic/genetics; Vaccines, Synthetic/isolation & purification; Viral Vaccines/administration & dosage; Viral Vaccines/isolation & purification; Viral Vaccines/standards