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Overall reduced lymphocyte especially T and B subsets closely related to the poor prognosis and the disease severity in severe patients with COVID-19 and diabetes mellitus.
Liu, Dafeng; Wang, Yong; Zhao, Bennan; Lan, Lijuan; Liu, Yaling; Bao, Lei; Chen, Hong; Yang, Min; Li, Qingfeng; Zeng, Yilan.
  • Liu D; Department of Internal Medicine, the Public and Health Clinic Centre of Chengdu, No. 18 Jingjusi Road, Jinjiang District, Chengdu, 610066, Sichuan, China. ldf312@126.com.
  • Wang Y; Department of Internal Medicine, the Public and Health Clinic Centre of Chengdu, No. 18 Jingjusi Road, Jinjiang District, Chengdu, 610066, Sichuan, China.
  • Zhao B; Department of Internal Medicine, the Public and Health Clinic Centre of Chengdu, No. 18 Jingjusi Road, Jinjiang District, Chengdu, 610066, Sichuan, China.
  • Lan L; Department of Internal Medicine, the Public and Health Clinic Centre of Chengdu, No. 18 Jingjusi Road, Jinjiang District, Chengdu, 610066, Sichuan, China.
  • Liu Y; Department of Internal Medicine, the Public and Health Clinic Centre of Chengdu, No. 18 Jingjusi Road, Jinjiang District, Chengdu, 610066, Sichuan, China.
  • Bao L; Department of Internal Medicine, the Public and Health Clinic Centre of Chengdu, No. 18 Jingjusi Road, Jinjiang District, Chengdu, 610066, Sichuan, China.
  • Chen H; Department of the Severe Second Ward, The Public and Health Clinic Centre of Chengdu, Chengdu, China.
  • Yang M; Department of the Tuberculosis First Ward, The Public and Health Clinic Centre of Chengdu, Chengdu, China.
  • Li Q; Department of Clinical Medical Laboratory, The Public and Health Clinic Centre of Chengdu, Chengdu, China.
  • Zeng Y; Department of Vice President's Office, The Public and Health Clinic Centre of Chengdu, No. 18 Jingjusi Road, Jinjiang District, Chengdu, 610066, Sichuan, China. 2499081791@qq.com.
Diabetol Metab Syndr ; 13(1): 5, 2021 Jan 12.
Article in English | MEDLINE | ID: covidwho-1024372
ABSTRACT

BACKGROUND:

A dysregulated host immune response is common in patients with COVID-19.

AIM:

In this study, we aimed to define the characteristics of lymphocyte subsets and their relationship with disease progression in COVID-19 patients with or without diabetes mellitus (DM).

METHODS:

The baseline peripheral lymphocyte subsets were compared between 55 healthy controls and 95 patients with confirmed COVID-19, and between severe and non-severe COVID-19 patients with or without DM.

RESULTS:

The prevalence of DM in the COVID-19 group was 20%, and patients with severe COVID-19 had a higher prevalence of DM than those with non-severe disease (P = 0.006). Moreover, a significantly poor prognosis and a higher rate of severity were found in those with DM relative to those without DM (P = 0.001, 0.003). Generally, all lymphocytes and subsets of lymphocytes, especially B and T cells, were significant reduced in COVID-19 patients, particularly in those with DM. Patients with severe COVID-19 and DM had the lowest lymphocyte counts compared with those with severe COVID-19 without DM, and those with non-severe COVID-19 with or without DM. Partially decreased lymphocyte subsets, age and DM were closely related to disease progression and prognosis.

CONCLUSIONS:

These findings provide a reference for clinicians that immunomodulatory treatment may improve disease progression and prognosis of COVID-19 patients, especially those with severe disease with DM. Trial registration Chinese Clinical Trial Register ChiCTR2000034563.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Randomized controlled trials Language: English Journal: Diabetol Metab Syndr Year: 2021 Document Type: Article Affiliation country: S13098-020-00622-3

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Randomized controlled trials Language: English Journal: Diabetol Metab Syndr Year: 2021 Document Type: Article Affiliation country: S13098-020-00622-3