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Synthesis and physicochemical studies of a series of mixed-ligand transition metal complexes and their molecular docking investigations against Coronavirus main protease
Open Chemistry ; 18(1):1495-1506, 2020.
Article in English | Web of Science | ID: covidwho-1024427
ABSTRACT
A novel series of mixed-ligand complexes of the type, [M(L-1)(L-2)Cl]center dot 2H(2)O [L-1 = 2-(alpha-methyl salicylidene hydrazine) benzimidazole (primary ligand), L-2 = 2,2'-bipyridine (bipy;secondary ligand), M = Co(n), Ni(n), Cu(n) and Zn(n)], were based on the physicoanalytical studies. The spectroscopic findings revealed tridentate nature of the Schiff base ligand (L-1) and its coordination to the metal ions via azomethine nitrogen, ring nitrogen and the deprotonated phenolic oxygen atoms. Furthermore, the synthesized compounds were evaluated for antimicrobial activity against Bacillus subtilis, Escherichia coli and Salmonella typhi microorganisms. In addition, molecular docking studies were carried out against Middle East respiratory syndrome coronavirus (PDB ID 4ZS6) and severe acute respiratory syndrome coronavirus 2 main protease (PDB ID 6W63).

Full text: Available Collection: Databases of international organizations Database: Web of Science Language: English Journal: Open Chemistry Year: 2020 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: Web of Science Language: English Journal: Open Chemistry Year: 2020 Document Type: Article