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Cytokines and Chemokines in SARS-CoV-2 Infections-Therapeutic Strategies Targeting Cytokine Storm.
Pum, Alexandra; Ennemoser, Maria; Adage, Tiziana; Kungl, Andreas J.
  • Pum A; Karl-Franzens-University Graz, Inst. Pharm. Sciences, Schubertstrasse 1, 8010 Graz, Austria.
  • Ennemoser M; Karl-Franzens-University Graz, Inst. Pharm. Sciences, Schubertstrasse 1, 8010 Graz, Austria.
  • Adage T; BIT Pharma, Leonhardstrasse 109, 8010 Graz, Austria.
  • Kungl AJ; Karl-Franzens-University Graz, Inst. Pharm. Sciences, Schubertstrasse 1, 8010 Graz, Austria.
Biomolecules ; 11(1)2021 Jan 12.
Article in English | MEDLINE | ID: covidwho-1024529
Semantic information from SemMedBD (by NLM)
1. cytokine ASSOCIATED_WITH COVID-19
Subject
cytokine
Predicate
ASSOCIATED_WITH
Object
COVID-19
2. chemokine ASSOCIATED_WITH COVID-19
Subject
chemokine
Predicate
ASSOCIATED_WITH
Object
COVID-19
3. Virus CAUSES Disease
Subject
Virus
Predicate
CAUSES
Object
Disease
4. Pandemics CAUSES Pneumonia
Subject
Pandemics
Predicate
CAUSES
Object
Pneumonia
5. Pandemics CAUSES Respiratory Distress Syndrom
Subject
Pandemics
Predicate
CAUSES
Object
Respiratory Distress Syndrom
6. Cytokine Storm CAUSES Coronavirus Infections
Subject
Cytokine Storm
Predicate
CAUSES
Object
Coronavirus Infections
7. Cytokine Release Syndrome CAUSES Coronavirus Infections
Subject
Cytokine Release Syndrome
Predicate
CAUSES
Object
Coronavirus Infections
8. Coronavirus Infections COEXISTS_WITH Borg Category-Ratio 10 Perceived Exertion Score 5
Subject
Coronavirus Infections
Predicate
COEXISTS_WITH
Object
Borg Category-Ratio 10 Perceived Exertion Score 5
9. cytokine ASSOCIATED_WITH Disease
Subject
cytokine
Predicate
ASSOCIATED_WITH
Object
Disease
10. chemokine ASSOCIATED_WITH Disease
Subject
chemokine
Predicate
ASSOCIATED_WITH
Object
Disease
11. Therapeutic procedure TREATS Coronavirus Infections
Subject
Therapeutic procedure
Predicate
TREATS
Object
Coronavirus Infections
12. cytokine ASSOCIATED_WITH COVID-19
Subject
cytokine
Predicate
ASSOCIATED_WITH
Object
COVID-19
13. chemokine ASSOCIATED_WITH COVID-19
Subject
chemokine
Predicate
ASSOCIATED_WITH
Object
COVID-19
14. Virus CAUSES Disease
Subject
Virus
Predicate
CAUSES
Object
Disease
15. Pandemics CAUSES Pneumonia
Subject
Pandemics
Predicate
CAUSES
Object
Pneumonia
16. Pandemics CAUSES Respiratory Distress Syndrome, Newborn
Subject
Pandemics
Predicate
CAUSES
Object
Respiratory Distress Syndrome, Newborn
17. Cytokine Storm CAUSES Coronavirus Infections
Subject
Cytokine Storm
Predicate
CAUSES
Object
Coronavirus Infections
18. Cytokine Release Syndrome CAUSES Coronavirus Infections
Subject
Cytokine Release Syndrome
Predicate
CAUSES
Object
Coronavirus Infections
19. Coronavirus Infections COEXISTS_WITH Borg Category-Ratio 10 Perceived Exertion Score 5
Subject
Coronavirus Infections
Predicate
COEXISTS_WITH
Object
Borg Category-Ratio 10 Perceived Exertion Score 5
20. cytokine ASSOCIATED_WITH Disease
Subject
cytokine
Predicate
ASSOCIATED_WITH
Object
Disease
21. chemokine ASSOCIATED_WITH Disease
Subject
chemokine
Predicate
ASSOCIATED_WITH
Object
Disease
22. Therapeutic procedure TREATS Coronavirus Infections
Subject
Therapeutic procedure
Predicate
TREATS
Object
Coronavirus Infections
ABSTRACT
The recently identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, the cause of coronavirus disease (COVID-19) and the associated ongoing pandemic, frequently leads to severe respiratory distress syndrome and pneumonia with fatal consequences. Although several factors of this infection and its consequences are not completely clear, the presence and involvement of specific chemokines is undoubtedly crucial for the development and progression of COVID-19. Cytokine storm and the often-resulting cytokine release syndrome (CRS) are pathophysiological hallmarks in COVID-19 infections related to its most severe and fatal cases. In this hyperinflammatory event, chemokines and other cytokines are highly upregulated and are therefore not fulfilling their beneficial function in the host response anymore but causing harmful effects. Here, we present the recent views on the involvement of chemokines and selected cytokines in COVID-19 and the therapeutics currently in clinical development targeting or interfering with them, discussing their potentials in the treatment of COVID-19 infections.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Cytokines / Cytokine Release Syndrome / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: Biom11010091

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cytokines / Cytokine Release Syndrome / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: Biom11010091