Characterizing Viral Infection by Electron Microscopy: Lessons from the Coronavirus Disease 2019 Pandemic.
Am J Pathol
; 191(2): 222-227, 2021 02.
Article
in English
| MEDLINE | ID: covidwho-1025412
ABSTRACT
The severe acute respiratory syndrome coronavirus 2 pandemic has infected millions of individuals in the United States and caused hundreds of thousands of deaths. Direct infection of extrapulmonary tissues has been postulated, and using sensitive techniques, viral RNA has been detected in multiple organs in the body, including the kidney. However, direct infection of tissues outside of the lung has been more challenging to demonstrate. This has been in part due to misinterpretation of electron microscopy studies. In this perspective, we will discuss what is known about coronavirus infection, some of the basic ultrastructural cell biology that has been confused for coronavirus infection of cells, and rigorous criteria that should be used when identifying pathogens by electron microscopy.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Microscopy, Electron
/
Coronavirus Infections
/
SARS-CoV-2
/
COVID-19
Type of study:
Diagnostic study
/
Observational study
Limits:
Humans
Country/Region as subject:
North America
Language:
English
Journal:
Am J Pathol
Year:
2021
Document Type:
Article
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