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Prolonged Unconsciousness Following Severe COVID-19.
Abdo, Wilson F; Broerse, Catharina I; Grady, Bart P; Wertenbroek, Agnes A A C M; Vijlbrief, Onno; Buise, Marc P; Beukema, Menno; van der Kuil, Mark; Tuladhar, Anil M; Meijer, Frederick J A; van der Hoeven, Johannes G.
  • Abdo WF; From the Departments of Intensive Care (W.F.A., J.G.v.d.H.), Neurology (C.I.B., A.M.T.), and Radiology (F.J.A.M.), Radboud University Medical Center, Nijmegen; Departments of Intensive Care (B.P.G.), Neurology (A.A.A.C.M.W.), and Radiology (O.V.), Ziekenhuisgroep Twente, Almelo; Department of Intens
  • Broerse CI; From the Departments of Intensive Care (W.F.A., J.G.v.d.H.), Neurology (C.I.B., A.M.T.), and Radiology (F.J.A.M.), Radboud University Medical Center, Nijmegen; Departments of Intensive Care (B.P.G.), Neurology (A.A.A.C.M.W.), and Radiology (O.V.), Ziekenhuisgroep Twente, Almelo; Department of Intens
  • Grady BP; From the Departments of Intensive Care (W.F.A., J.G.v.d.H.), Neurology (C.I.B., A.M.T.), and Radiology (F.J.A.M.), Radboud University Medical Center, Nijmegen; Departments of Intensive Care (B.P.G.), Neurology (A.A.A.C.M.W.), and Radiology (O.V.), Ziekenhuisgroep Twente, Almelo; Department of Intens
  • Wertenbroek AAACM; From the Departments of Intensive Care (W.F.A., J.G.v.d.H.), Neurology (C.I.B., A.M.T.), and Radiology (F.J.A.M.), Radboud University Medical Center, Nijmegen; Departments of Intensive Care (B.P.G.), Neurology (A.A.A.C.M.W.), and Radiology (O.V.), Ziekenhuisgroep Twente, Almelo; Department of Intens
  • Vijlbrief O; From the Departments of Intensive Care (W.F.A., J.G.v.d.H.), Neurology (C.I.B., A.M.T.), and Radiology (F.J.A.M.), Radboud University Medical Center, Nijmegen; Departments of Intensive Care (B.P.G.), Neurology (A.A.A.C.M.W.), and Radiology (O.V.), Ziekenhuisgroep Twente, Almelo; Department of Intens
  • Buise MP; From the Departments of Intensive Care (W.F.A., J.G.v.d.H.), Neurology (C.I.B., A.M.T.), and Radiology (F.J.A.M.), Radboud University Medical Center, Nijmegen; Departments of Intensive Care (B.P.G.), Neurology (A.A.A.C.M.W.), and Radiology (O.V.), Ziekenhuisgroep Twente, Almelo; Department of Intens
  • Beukema M; From the Departments of Intensive Care (W.F.A., J.G.v.d.H.), Neurology (C.I.B., A.M.T.), and Radiology (F.J.A.M.), Radboud University Medical Center, Nijmegen; Departments of Intensive Care (B.P.G.), Neurology (A.A.A.C.M.W.), and Radiology (O.V.), Ziekenhuisgroep Twente, Almelo; Department of Intens
  • van der Kuil M; From the Departments of Intensive Care (W.F.A., J.G.v.d.H.), Neurology (C.I.B., A.M.T.), and Radiology (F.J.A.M.), Radboud University Medical Center, Nijmegen; Departments of Intensive Care (B.P.G.), Neurology (A.A.A.C.M.W.), and Radiology (O.V.), Ziekenhuisgroep Twente, Almelo; Department of Intens
  • Tuladhar AM; From the Departments of Intensive Care (W.F.A., J.G.v.d.H.), Neurology (C.I.B., A.M.T.), and Radiology (F.J.A.M.), Radboud University Medical Center, Nijmegen; Departments of Intensive Care (B.P.G.), Neurology (A.A.A.C.M.W.), and Radiology (O.V.), Ziekenhuisgroep Twente, Almelo; Department of Intens
  • Meijer FJA; From the Departments of Intensive Care (W.F.A., J.G.v.d.H.), Neurology (C.I.B., A.M.T.), and Radiology (F.J.A.M.), Radboud University Medical Center, Nijmegen; Departments of Intensive Care (B.P.G.), Neurology (A.A.A.C.M.W.), and Radiology (O.V.), Ziekenhuisgroep Twente, Almelo; Department of Intens
  • van der Hoeven JG; From the Departments of Intensive Care (W.F.A., J.G.v.d.H.), Neurology (C.I.B., A.M.T.), and Radiology (F.J.A.M.), Radboud University Medical Center, Nijmegen; Departments of Intensive Care (B.P.G.), Neurology (A.A.A.C.M.W.), and Radiology (O.V.), Ziekenhuisgroep Twente, Almelo; Department of Intens
Neurology ; 96(10): e1437-e1442, 2021 03 09.
Article in English | MEDLINE | ID: covidwho-1027729
ABSTRACT

OBJECTIVE:

We report a case series of patients with prolonged but reversible unconsciousness after coronavirus disease 2019 (COVID-19)-related severe respiratory failure.

METHODS:

A case series of patients who were admitted to the intensive care unit due to COVID-19-related acute respiratory failure is described.

RESULTS:

After cessation of sedatives, the described cases all showed a prolonged comatose state. Diagnostic neurologic workup did not show signs of devastating brain injury. The clinical pattern of awakening started with early eye opening without obeying commands and persistent flaccid weakness in all cases. Time between cessation of sedatives to the first moment of being fully responsive with obeying commands ranged from 8 to 31 days.

CONCLUSION:

Prolonged unconsciousness in patients with severe respiratory failure due to COVID-19 can be fully reversible, warranting a cautious approach for prognostication based on a prolonged state of unconsciousness.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Insufficiency / Coma / COVID-19 Type of study: Case report / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Neurology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Insufficiency / Coma / COVID-19 Type of study: Case report / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Neurology Year: 2021 Document Type: Article