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Increased Fecal Neopterin Parallels Gastrointestinal Symptoms in COVID-19.
Grabherr, Felix; Effenberger, Maria; Pedrini, Alisa; Mayr, Lisa; Schwärzler, Julian; Reider, Simon; Enrich, Barbara; Fritsche, Gernot; Wildner, Sophie; Bellmann-Weiler, Rosa; Weiss, Günter; Scholl-Bürgi, Sabine; Müller, Thomas; Moschen, Alexander; Adolph, Timon E; Tilg, Herbert.
  • Grabherr F; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Innsbruck, Austria.
  • Effenberger M; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Innsbruck, Austria.
  • Pedrini A; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Innsbruck, Austria.
  • Mayr L; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Innsbruck, Austria.
  • Schwärzler J; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Innsbruck, Austria.
  • Reider S; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Innsbruck, Austria.
  • Enrich B; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Innsbruck, Austria.
  • Fritsche G; Department of Internal Medicine II, Infectious Disease, Pulmonology & Rheumatology, Medical University of Innsbruck, Innsbruck, Austria.
  • Wildner S; Department of Internal Medicine II, Infectious Disease, Pulmonology & Rheumatology, Medical University of Innsbruck, Innsbruck, Austria.
  • Bellmann-Weiler R; Department of Internal Medicine II, Infectious Disease, Pulmonology & Rheumatology, Medical University of Innsbruck, Innsbruck, Austria.
  • Weiss G; Department of Internal Medicine II, Infectious Disease, Pulmonology & Rheumatology, Medical University of Innsbruck, Innsbruck, Austria.
  • Scholl-Bürgi S; Department of Pediatrics I, Medical University of Innsbruck, Innsbruck, Austria.
  • Müller T; Department of Pediatrics I, Medical University of Innsbruck, Innsbruck, Austria.
  • Moschen A; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Innsbruck, Austria.
  • Adolph TE; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Innsbruck, Austria.
  • Tilg H; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Innsbruck, Austria.
Clin Transl Gastroenterol ; 12(1): e00293, 2021 01 12.
Article in English | MEDLINE | ID: covidwho-1028690
ABSTRACT

INTRODUCTION:

Coronavirus disease (COVID-19) has spread from Wuhan, China, and become a worldwide pandemic. Most patients display respiratory symptoms but up to 50% report gastrointestinal symptoms. Neopterin is a surrogate marker for viral inflammation, and its production by macrophages is driven by interferon-γ.

METHODS:

We measured fecal neopterin in 37 hospitalized COVID-19 patients not requiring intensive care measures and 22 healthy controls.

RESULTS:

Fecal neopterin was elevated in stool samples from COVID-19 patients compared with that in samples from healthy controls. Especially, patients reporting gastrointestinal symptoms exhibited increased fecal neopterin values.

DISCUSSION:

COVID-19 is associated with an inflammatory immune response in the gastrointestinal tract.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neopterin / Feces / Gastrointestinal Diseases / COVID-19 Type of study: Diagnostic study / Observational study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Clin Transl Gastroenterol Year: 2021 Document Type: Article Affiliation country: Ctg.0000000000000293

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neopterin / Feces / Gastrointestinal Diseases / COVID-19 Type of study: Diagnostic study / Observational study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Clin Transl Gastroenterol Year: 2021 Document Type: Article Affiliation country: Ctg.0000000000000293