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Strategic vision for improving human health at The Forefront of Genomics.
Green, Eric D; Gunter, Chris; Biesecker, Leslie G; Di Francesco, Valentina; Easter, Carla L; Feingold, Elise A; Felsenfeld, Adam L; Kaufman, David J; Ostrander, Elaine A; Pavan, William J; Phillippy, Adam M; Wise, Anastasia L; Dayal, Jyoti Gupta; Kish, Britny J; Mandich, Allison; Wellington, Christopher R; Wetterstrand, Kris A; Bates, Sarah A; Leja, Darryl; Vasquez, Susan; Gahl, William A; Graham, Bettie J; Kastner, Daniel L; Liu, Paul; Rodriguez, Laura Lyman; Solomon, Benjamin D; Bonham, Vence L; Brody, Lawrence C; Hutter, Carolyn M; Manolio, Teri A.
  • Green ED; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA. egreen@nhgri.nih.gov.
  • Gunter C; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Biesecker LG; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Di Francesco V; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Easter CL; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Feingold EA; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Felsenfeld AL; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Kaufman DJ; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Ostrander EA; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Pavan WJ; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Phillippy AM; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Wise AL; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Dayal JG; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Kish BJ; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Mandich A; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Wellington CR; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Wetterstrand KA; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Bates SA; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Leja D; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Vasquez S; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Gahl WA; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Graham BJ; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Kastner DL; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Liu P; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Rodriguez LL; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Solomon BD; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Bonham VL; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Brody LC; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Hutter CM; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Manolio TA; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Nature ; 586(7831): 683-692, 2020 10.
Article in English | MEDLINE | ID: covidwho-1028698
ABSTRACT
Starting with the launch of the Human Genome Project three decades ago, and continuing after its completion in 2003, genomics has progressively come to have a central and catalytic role in basic and translational research. In addition, studies increasingly demonstrate how genomic information can be effectively used in clinical care. In the future, the anticipated advances in technology development, biological insights, and clinical applications (among others) will lead to more widespread integration of genomics into almost all areas of biomedical research, the adoption of genomics into mainstream medical and public-health practices, and an increasing relevance of genomics for everyday life. On behalf of the research community, the National Human Genome Research Institute recently completed a multi-year process of strategic engagement to identify future research priorities and opportunities in human genomics, with an emphasis on health applications. Here we describe the highest-priority elements envisioned for the cutting-edge of human genomics going forward-that is, at 'The Forefront of Genomics'.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Genome, Human / Public Health / Genomics / Biomedical Research / Translational Research, Biomedical Type of study: Prognostic study Limits: Humans Country/Region as subject: North America Language: English Journal: Nature Year: 2020 Document Type: Article Affiliation country: S41586-020-2817-4

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Genome, Human / Public Health / Genomics / Biomedical Research / Translational Research, Biomedical Type of study: Prognostic study Limits: Humans Country/Region as subject: North America Language: English Journal: Nature Year: 2020 Document Type: Article Affiliation country: S41586-020-2817-4