[APOBEC3s: history of an antiviral and mutagenic protein family]. / Les APOBEC3 : histoire d'une famille de protéines antivirales et mutagènes.
Virologie (Montrouge)
; 24(6): 381-418, 2020 12 01.
Article
in French
| MEDLINE | ID: covidwho-1030336
ABSTRACT
The innate immune response is nonspecific and constitutes the first line of defense against infections by pathogens, mainly by enabling their elimination by phagocytosis or apoptosis. In immune cells, this response is characterized, amongst others, by the synthesis of restriction factors, a class of proteins whose role is to inhibit viral replication. Among them, the proteins of the APOBEC3 (Apolipoprotein B mRNA-editing Enzyme Catalytic polypeptide-like 3 or A3) family are major antiviral factors that target a wide range of viruses. One of their targets is the Human Immunodeficiency Virus Type 1 (HIV-1) the deaminase activity of some A3 proteins converts a fraction of cytidines of the viral genome into uridines, impairing its expression. Nevertheless, HIV-1 counteracts A3 proteins thanks to its Vif protein, which inhibits them by hijacking several cellular mechanisms. Besides, APOBEC3 proteins help maintaining the genome integrity by inhibiting retroelements but they also contribute to carcinogenesis, as it is the case for A3A and A3B, two major factors in this process. The large range of A3 activities, combined with recent studies showing their implication in the regulation of emerging viruses (Zika, SARS-CoV-2), allow A3 and their viral partners to be considered as therapeutic areas.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
APOBEC Deaminases
/
COVID-19
/
Immunity, Innate
Type of study:
Prognostic study
Limits:
Adult
/
Animals
/
Humans
Language:
French
Journal:
Virologie (Montrouge)
Year:
2020
Document Type:
Article
Affiliation country:
Vir.2020.0870
Similar
MEDLINE
...
LILACS
LIS