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Hydroxychloroquine in COVID-19: therapeutic promises, current status, and environmental implications.
Kumar, Rajnish; Sharma, Anju; Srivastava, Janmejai Kumar; Siddiqui, Mohammed Haris; Uddin, Md Sahab; Aleya, Lotfi.
  • Kumar R; Amity Institute of Biotechnology, Amity University Uttar Pradesh Lucknow Campus, Uttar Pradesh, India. rkumar2@lko.amity.edu.
  • Sharma A; Department of Applied Science, Indian Institute of Information Technology, Allahabad, Uttar Pradesh, India.
  • Srivastava JK; Amity Institute of Biotechnology, Amity University Uttar Pradesh Lucknow Campus, Uttar Pradesh, India.
  • Siddiqui MH; Department of Bioengineering, Integral University, Lucknow, Uttar Pradesh, India.
  • Uddin MS; Department of Pharmacy, Southeast University, Dhaka, Bangladesh. msu-neuropharma@hotmail.com.
  • Aleya L; Pharmakon Neuroscience Research Network, Dhaka, Bangladesh. msu-neuropharma@hotmail.com.
Environ Sci Pollut Res Int ; 28(30): 40431-40444, 2021 Aug.
Article in English | MEDLINE | ID: covidwho-1030736
ABSTRACT
The outbreak of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected the entire world with its infectious spread and mortality rate. The severe cases of coronavirus disease 2019 (COVID-19) are characterized by hypoxia and acute respiratory distress syndrome. In the absence of any specific treatment, just the preventive and supportive care options are available. Therefore, much focus is given to assess the available therapeutic options not only to avoid acute respiratory failure and hypoxia but also to reduce the viral load to control the severity of the disease. The antimalarial drug hydroxychloroquine (HCQ) is among the much-discussed drugs for the treatment and management of COVID-19 patients. This article reviews the therapeutic potential of HCQ in the treatment of COVID-19 based on the available in vitro and clinical evidence, current status of registered HCQ-based clinical trials investigating therapeutic options for COVID-19, and environmental implications of HCQ.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronavirus Infections / COVID-19 Limits: Humans Language: English Journal: Environ Sci Pollut Res Int Journal subject: Environmental Health / Toxicology Year: 2021 Document Type: Article Affiliation country: S11356-020-12200-1

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronavirus Infections / COVID-19 Limits: Humans Language: English Journal: Environ Sci Pollut Res Int Journal subject: Environmental Health / Toxicology Year: 2021 Document Type: Article Affiliation country: S11356-020-12200-1