High incidence of Epstein-Barr virus, cytomegalovirus, and human-herpes virus-6 reactivations in critically ill patients with COVID-19.
Infect Dis Now
; 51(3): 296-299, 2021 May.
Article
in English
| MEDLINE | ID: covidwho-1032305
ABSTRACT
BACKGROUND:
Systemic reactivation of herpesviruses may occur in intensive care unit (ICU) patients and is associated with morbidity and mortality. Data on severe Coronavirus disease-19 (COVID-19) and concomitant reactivation of herpesviruses are lacking.METHODS:
We selected patients admitted to ICU for confirmed COVID-19 who underwent systematic testing for Epstein-Barr virus (EBV), cytomegalovirus (CMV) and human-herpes virus-6 (HHV-6) DNAemia while in the ICU. We retrospectively analysed frequency, timing, duration and co-occurrence of viral DNAemia.RESULTS:
Thirty-four patients were included. Viremia with EBV, CMV, and HHV-6 was detected in 28 (82%), 5 (15%), and 7 (22%) patients, respectively. EBV reactivation occurred early after ICU admission and was associated with longer ICU length-of-stay.CONCLUSIONS:
While in the ICU, critically ill patients with COVID-19 are prone to develop reactivations due to various types of herpesviruses.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Virus Activation
/
Herpesvirus 6, Human
/
Herpesvirus 4, Human
/
Cytomegalovirus
/
Latent Infection
/
COVID-19
Type of study:
Observational study
/
Systematic review/Meta Analysis
Topics:
Long Covid
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
English
Journal:
Infect Dis Now
Year:
2021
Document Type:
Article
Affiliation country:
J.idnow.2021.01.005
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