Your browser doesn't support javascript.
What is the relationship between validated frailty scores and mortality for adults with COVID-19 in acute hospital care? A systematic review.
Cosco, Theodore D; Best, John; Davis, Daniel; Bryden, Daniele; Arkill, Suzanne; van Oppen, James; Riadi, Indira; Wagner, Kevin R; Conroy, Simon.
  • Cosco TD; Department of Gerontology, Simon Fraser University, Vancouver, Canada.
  • Best J; Department of Gerontology, Simon Fraser University, Vancouver, Canada.
  • Davis D; University College London, London, UK.
  • Bryden D; Sheffield Teaching Hospitals, Sheffield, UK.
  • Arkill S; University Hospitals of Leicester, Leicester, UK.
  • van Oppen J; Department of Health Sciences, University of Leicester, University Road, Leicester LE1 7RH, UK.
  • Riadi I; Department of Gerontology, Simon Fraser University, Vancouver, Canada.
  • Wagner KR; Simon Fraser University, Vancouver, Canada.
  • Conroy S; Department of Health Sciences, University of Leicester, University Road, Leicester LE1 7RH, UK.
Age Ageing ; 50(3): 608-616, 2021 05 05.
Article in English | MEDLINE | ID: covidwho-1032411
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
See preprint
ABSTRACT
BACKGROUND AND

AIM:

The aim of this systematic review was to quantify the association between frailty and COVID-19 in relation to mortality in hospitalised patients.

METHODS:

Medline, Embase, Web of Science and the grey literature were searched for papers from inception to 10 September 2020; the search was re-run in Medline up until the 9 December 2020. Screening, data extraction and quality grading were undertaken by two reviewers. Results were summarised using descriptive statistics, including a meta-analysis of overall mortality; the relationships between frailty and COVID-19 mortality were summarised narratively.

RESULTS:

A total of 2,286 papers were screened resulting in 26 being included in the review. Most studies were from Europe, half from the UK, and one from Brazil; the median sample size was 242.5, median age 73.1 and 43.5% were female. In total, 22/26 used the Clinical Frailty Scale; reported mortality ranged from 14 to 65%. Most, but not all studies showed an association between increasing frailty and a greater risk of dying. Two studies indicated a sub-additive relationship between frailty, COVID-19 and death, and two studies showed no association.

CONCLUSIONS:

Whilst the majority of studies have shown a positive association between COVID-19-related death and increasing frailty, some studies suggested a more nuanced understanding of frailty and outcomes in COVID-19 is needed. Clinicians should exert caution in placing too much emphasis on the influence of frailty alone when discussing likely prognosis in older people with COVID-19 illness.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Frail Elderly / Hospital Mortality / Frailty / COVID-19 Type of study: Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Topics: Long Covid Limits: Aged / Female / Humans / Male Language: English Journal: Age Ageing Year: 2021 Document Type: Article Affiliation country: Ageing

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Frail Elderly / Hospital Mortality / Frailty / COVID-19 Type of study: Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Topics: Long Covid Limits: Aged / Female / Humans / Male Language: English Journal: Age Ageing Year: 2021 Document Type: Article Affiliation country: Ageing