Your browser doesn't support javascript.
Bioactive Lipids of Marine Microalga Chlorococcum sp. SABC 012504 with Anti-Inflammatory and Anti-Thrombotic Activities.
Shiels, Katie; Tsoupras, Alexandros; Lordan, Ronan; Nasopoulou, Constantina; Zabetakis, Ioannis; Murray, Patrick; Saha, Sushanta Kumar.
  • Shiels K; Shannon Applied Biotechnology Centre, Limerick Institute of Technology, Moylish Park, V94 E8YF Limerick, Ireland.
  • Tsoupras A; Department of Biological Sciences, University of Limerick, V94 T9PX Limerick, Ireland.
  • Lordan R; Health Research Institute, University of Limerick, V94 T9PX Limerick, Ireland.
  • Nasopoulou C; Bernal Institute, University of Limerick, V94 T9PX Limerick, Ireland.
  • Zabetakis I; Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Murray P; Department of Food Science and Nutrition, School of the Environment, University of the Aegean, GR 81400 Myrina, Lemnos, Greece.
  • Saha SK; Department of Biological Sciences, University of Limerick, V94 T9PX Limerick, Ireland.
Mar Drugs ; 19(1)2021 Jan 10.
Article in English | MEDLINE | ID: covidwho-1033055
Semantic information from SemMedBD (by NLM)
1. Platelet PROCESS_OF C0086418
Subject
Platelet
Predicate
PROCESS_OF
Object
C0086418
2. Antithrombin III Measurement DIAGNOSES Platelet
Subject
Antithrombin III Measurement
Predicate
DIAGNOSES
Object
Platelet
3. Platelets, CTCAE PROCESS_OF Homo sapiens
Subject
Platelets, CTCAE
Predicate
PROCESS_OF
Object
Homo sapiens
4. Antithrombin III Measurement DIAGNOSES Platelets, CTCAE
Subject
Antithrombin III Measurement
Predicate
DIAGNOSES
Object
Platelets, CTCAE
ABSTRACT
Microalgae are at the start of the food chain, and many are known producers of a significant amount of lipids with essential fatty acids. However, the bioactivity of microalgal lipids for anti-inflammatory and antithrombotic activities have rarely been investigated. Therefore, for a sustainable source of the above bioactive lipids, the present study was undertaken. The total lipids of microalga Chlorococcum sp., isolated from the Irish coast, were fractionated into neutral-, glyco-, and phospho-lipids, and were tested in vitro for their anti-inflammatory and antithrombotic activities. All tested lipid fractions showed strong anti-platelet-activating factor (PAF) and antithrombin activities in human platelets (half maximal inhibitory concentration (IC50) values ranging ~25-200 µg of lipid) with the highest activities in glyco- and phospho-lipid fractions. The structural analysis of the bioactive lipid fraction-2 revealed the presence of specific sulfoquinovosyl diacylglycerols (SQDG) bioactive molecules and the HexCer-t362 (t181/181 and 182/180) cerebrosides with a phytosphingosine (4-hydrosphinganine) base, while fraction-3 contained bioactive phosphatidylcholine (PC) and phosphatidylethanolamine (PE) molecules. These novel bioactive lipids of Chlorococcum sp. with putative health benefits may indicate that marine microalgae can be a sustainable alternative source for bioactive lipids production for food supplements and nutraceutical applications. However, further studies are required towards the commercial technology pathways development and biosafety analysis for the use of the microalga.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Anti-Inflammatory Agents, Non-Steroidal / Microalgae / Fibrinolytic Agents / Lipids Limits: Humans Language: English Journal subject: Biology / Pharmacology Year: 2021 Document Type: Article Affiliation country: Md19010028

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Anti-Inflammatory Agents, Non-Steroidal / Microalgae / Fibrinolytic Agents / Lipids Limits: Humans Language: English Journal subject: Biology / Pharmacology Year: 2021 Document Type: Article Affiliation country: Md19010028