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The impact of COVID-19 infection on the cytokine profile of pregnant women: A prospective case-control study.
Tanacan, Atakan; Yazihan, Nuray; Erol, Seyit Ahmet; Anuk, Ali Taner; Yucel Yetiskin, Fatma Didem; Biriken, Derya; Ozgu-Erdinc, A Seval; Keskin, Huseyin Levent; Moraloglu Tekin, Ozlem; Sahin, Dilek.
  • Tanacan A; Department of Obstetrics and Gynecology, Turkish Ministry of Health Ankara City Hospital, Ankara, Turkey. Electronic address: atakantanacan@yahoo.com.
  • Yazihan N; Ankara University, Faculty of Medicine, Internal Medicine, Pathophysiology Department, Ankara University, Institute of Health Sciences, Interdisciplinary Food, Metabolism and Clinical Nutrition Department, Ankara, Turkey.
  • Erol SA; Department of Obstetrics and Gynecology, Turkish Ministry of Health Ankara City Hospital, Ankara, Turkey.
  • Anuk AT; Department of Obstetrics and Gynecology, Turkish Ministry of Health Ankara City Hospital, Ankara, Turkey.
  • Yucel Yetiskin FD; Department of Obstetrics and Gynecology, Turkish Ministry of Health Ankara City Hospital, Ankara, Turkey.
  • Biriken D; Department of Microbiology, Ankara University, Ankara, Turkey.
  • Ozgu-Erdinc AS; Department of Obstetrics and Gynecology, Turkish Ministry of Health Ankara City Hospital, Ankara, Turkey.
  • Keskin HL; University of Health Sciences, Turkish Ministry of Health, Ankara City Hospital, Ankara, Turkey.
  • Moraloglu Tekin O; University of Health Sciences, Turkish Ministry of Health, Ankara City Hospital, Ankara, Turkey.
  • Sahin D; University of Health Sciences, Turkish Ministry of Health, Ankara City Hospital, Ankara, Turkey.
Cytokine ; 140: 155431, 2021 04.
Article in English | MEDLINE | ID: covidwho-1033094
ABSTRACT

OBJECTIVE:

To compare the levels of various cytokines between pregnant women with confirmed coronavirus disease (COVID-19) infection and pregnant women without any defined risk factor. MATERIALS AND

METHODS:

Pregnant women with confirmed COVID-19 infection (study group)(n = 90) were prospectively compared to a gestational age-matched control group of pregnant women without any defined risk factors (n = 90). Demographic features, clinical characteristics, laboratory parameters, interferon-gamma (IFN γ), interleukin (IL-2), IL-6, IL-10, and IL-17 levels were compared between the groups. Additionally, a correlation analysis was performed in the study group for the assessment of IFN γ, IL-2, IL-6, IL-10, and IL-17 levels with disease severity and CRP levels.

RESULTS:

Study group had significantly higher pregnancy complication rate, erythrocyte sedimentation rate, C-reactive protein, procalcitonin, ferritin, D-dimer, lactate dehydrogenase, IFN γ, and IL-6 values (p < 0.05). On the other hand, the control group had significantly higher hemoglobin, leukocyte, platelet, lymphocyte, IL-2, IL-10, and IL-17 values (p < 0.05). Statistically significant differences were found between the groups for IFN γ, IL-2, IL-10, and IL-17 values between the trimesters (p < 0.05). Statistically significant positive correlations were found for IFN γ and IL-6 with disease severity (r = 0.41 and p < 0.001 for IFN γ and r = 0.58 and p < 0.001 for IL-6). On the other hand, a moderate negative correlation for IL-2 and a weak negative correlation for IL-10 were present (r = -0.62 and p < 0.001 for IL-2 and r = -0.19 and p = 0.01 for IL-10). A statistically significant positive moderate correlation was found between IL-6 and CRP (r = 0.40 and p < 0.001)

CONCLUSION:

COVID-19 infection seems to have an impact on the cytokine profile of pregnant women varying according to pregnancy trimesters and cytokine levels seem to be correlated with disease severity.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Cytokines / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Variants Limits: Female / Humans / Pregnancy Language: English Journal: Cytokine Journal subject: Allergy and Immunology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Cytokines / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Variants Limits: Female / Humans / Pregnancy Language: English Journal: Cytokine Journal subject: Allergy and Immunology Year: 2021 Document Type: Article