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Do not neglect SARS-CoV-2 hospitalization and fatality risks in the middle-aged adult population.
Lapidus, Nathanael; Paireau, Juliette; Levy-Bruhl, Daniel; de Lamballerie, Xavier; Severi, Gianluca; Touvier, Mathilde; Zins, Marie; Cauchemez, Simon; Carrat, Fabrice.
  • Lapidus N; Sorbonne Université, Inserm, Institut Pierre-Louis d'Epidémiologie et de Santé Publique, Département de Santé Publique, Hôpital Saint-Antoine, APHP, Paris, France. Electronic address: nathanael.lapidus@inserm.fr.
  • Paireau J; Mathematical Modelling of Infectious Diseases Unit, Institut Pasteur, UMR2000, CNRS, Paris, France; Santé Publique France, French National Public Health Agency, Saint-Maurice, France.
  • Levy-Bruhl D; Santé Publique France, French National Public Health Agency, Saint-Maurice, France.
  • de Lamballerie X; Unité des Virus Emergents, UVE: Aix Marseille Univ, IRD 190, Inserm 1207, IHU Méditerranée Infection, 13005 Marseille, France.
  • Severi G; Department of Statistics, Computer Science and Applications, University of Florence, Italy; CESP UMR1018, Université Paris-Saclay, UVSQ, Inserm, Gustave Roussy, Villejuif, France.
  • Touvier M; Sorbonne Paris Nord University, Inserm U1153, Inrae U1125, Cnam, Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Center-University of Paris (CRESS), Bobigny, France.
  • Zins M; Paris University, Paris, France; Paris Saclay University, Inserm UMS 11, Villejuif, France.
  • Cauchemez S; Mathematical Modelling of Infectious Diseases Unit, Institut Pasteur, UMR2000, CNRS, Paris, France.
  • Carrat F; Sorbonne Université, Inserm, Institut Pierre-Louis d'Epidémiologie et de Santé Publique, Département de Santé Publique, Hôpital Saint-Antoine, APHP, Paris, France.
Infect Dis Now ; 51(4): 380-382, 2021 Jun.
Article in English | MEDLINE | ID: covidwho-1033154
ABSTRACT

OBJECTIVES:

This study aimed at estimating the SARS-CoV-2 infection hospitalization (IHR) and infection fatality ratios (IFR) in France. PATIENTS AND

METHODS:

A serosurvey was conducted in 9782 subjects from the two French regions with the highest incidence of COVID-19 during the first wave of the pandemic and coupled with surveillance data.

RESULTS:

IHR and IFR were 2.7% and 0.49% overall. Both were higher in men and increased exponentially with age. The relative risks of hospitalization and death were 2.1 (95% CI 1.9-2.3) and 3.8 (2.4-4.2) per 10-year increase, meaning that IHR and IFR approximately doubled every 10 and 5 years, respectively. They were dramatically high in the very elderly (80-90 years IHR 26%, IFR 9.2%), and also substantial in younger adults (40-50 years IHR 0.98%, IFR 0.042%).

CONCLUSIONS:

These findings support the need for comprehensive preventive measures to help reduce the spread of the virus, even in young or middle-aged adults.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Hospitalization Type of study: Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Europa Language: English Journal: Infect Dis Now Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Hospitalization Type of study: Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Europa Language: English Journal: Infect Dis Now Year: 2021 Document Type: Article