Your browser doesn't support javascript.
Susceptibility-weighted imaging reveals cerebral microvascular injury in severe COVID-19.
Conklin, John; Frosch, Matthew P; Mukerji, Shibani S; Rapalino, Otto; Maher, Mary D; Schaefer, Pamela W; Lev, Michael H; Gonzalez, R G; Das, Sudeshna; Champion, Samantha N; Magdamo, Colin; Sen, Pritha; Harrold, G Kyle; Alabsi, Haitham; Normandin, Erica; Shaw, Bennett; Lemieux, Jacob E; Sabeti, Pardis C; Branda, John A; Brown, Emery N; Westover, M Brandon; Huang, Susie Y; Edlow, Brian L.
  • Conklin J; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States of America.
  • Frosch MP; C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Boston, MA, USA; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America.
  • Mukerji SS; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America.
  • Rapalino O; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America.
  • Maher MD; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America.
  • Schaefer PW; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America.
  • Lev MH; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America.
  • Gonzalez RG; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America.
  • Das S; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America.
  • Champion SN; C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Boston, MA, USA.
  • Magdamo C; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America.
  • Sen P; Division of Infectious Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America.
  • Harrold GK; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America.
  • Alabsi H; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America.
  • Normandin E; Broad Institute, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, United States of America.
  • Shaw B; Division of Infectious Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America; Broad Institute, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, United States of America.
  • Lemieux JE; Division of Infectious Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America.
  • Sabeti PC; Broad Institute, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, United States of America.
  • Branda JA; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, United States of America.
  • Brown EN; Department of Anesthesia, Critical Care & Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America.
  • Westover MB; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America.
  • Huang SY; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States of America.
  • Edlow BL; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States of America; Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA, United States of America; Department of Neurology, Massachusetts General Hospital
J Neurol Sci ; 421: 117308, 2021 02 15.
Article in English | MEDLINE | ID: covidwho-1033825
Semantic information from SemMedBD (by NLM)
1. Susceptibility Weighted Imaging DIAGNOSES Brain Injuries
Subject
Susceptibility Weighted Imaging
Predicate
DIAGNOSES
Object
Brain Injuries
2. Brain Injuries COEXISTS_WITH COVID-19
Subject
Brain Injuries
Predicate
COEXISTS_WITH
Object
COVID-19
3. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
4. Lesion of brain OCCURS_IN Patients
Subject
Lesion of brain
Predicate
OCCURS_IN
Object
Patients
5. Evaluation USES Nuclear magnetic resonance imaging brain
Subject
Evaluation
Predicate
USES
Object
Nuclear magnetic resonance imaging brain
6. Nuclear magnetic resonance imaging brain ADMINISTERED_TO Patients
Subject
Nuclear magnetic resonance imaging brain
Predicate
ADMINISTERED_TO
Object
Patients
7. Lesion PROCESS_OF Patients
Subject
Lesion
Predicate
PROCESS_OF
Object
Patients
8. Subcortical LOCATION_OF Lesion
Subject
Subcortical
Predicate
LOCATION_OF
Object
Lesion
9. Disseminated Intravascular Coagulation PROCESS_OF Patients
Subject
Disseminated Intravascular Coagulation
Predicate
PROCESS_OF
Object
Patients
10. Septicemia PROCESS_OF Patients
Subject
Septicemia
Predicate
PROCESS_OF
Object
Patients
11. Respiratory Failure PROCESS_OF Patients
Subject
Respiratory Failure
Predicate
PROCESS_OF
Object
Patients
12. Brain LOCATION_OF Autopsy
Subject
Brain
Predicate
LOCATION_OF
Object
Autopsy
13. Susceptibility Weighted Imaging DIAGNOSES Brain Injuries
Subject
Susceptibility Weighted Imaging
Predicate
DIAGNOSES
Object
Brain Injuries
14. Brain Injuries COEXISTS_WITH COVID-19
Subject
Brain Injuries
Predicate
COEXISTS_WITH
Object
COVID-19
15. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
16. Lesion of brain OCCURS_IN Patients
Subject
Lesion of brain
Predicate
OCCURS_IN
Object
Patients
17. Evaluation USES Nuclear magnetic resonance imaging brain
Subject
Evaluation
Predicate
USES
Object
Nuclear magnetic resonance imaging brain
18. Nuclear magnetic resonance imaging brain ADMINISTERED_TO Patients
Subject
Nuclear magnetic resonance imaging brain
Predicate
ADMINISTERED_TO
Object
Patients
19. Lesion PROCESS_OF Patients
Subject
Lesion
Predicate
PROCESS_OF
Object
Patients
20. Subcortical LOCATION_OF Lesion
Subject
Subcortical
Predicate
LOCATION_OF
Object
Lesion
21. Disseminated Intravascular Coagulation PROCESS_OF Patients
Subject
Disseminated Intravascular Coagulation
Predicate
PROCESS_OF
Object
Patients
22. Septicemia PROCESS_OF Patients
Subject
Septicemia
Predicate
PROCESS_OF
Object
Patients
23. Respiratory Failure PROCESS_OF Patients
Subject
Respiratory Failure
Predicate
PROCESS_OF
Object
Patients
24. Brain LOCATION_OF Autopsy
Subject
Brain
Predicate
LOCATION_OF
Object
Autopsy
ABSTRACT
We evaluated the incidence, distribution, and histopathologic correlates of microvascular brain lesions in patients with severe COVID-19. Sixteen consecutive patients admitted to the intensive care unit with severe COVID-19 undergoing brain MRI for evaluation of coma or neurologic deficits were retrospectively identified. Eleven patients had punctate susceptibility-weighted imaging (SWI) lesions in the subcortical and deep white matter, eight patients had >10 SWI lesions, and four patients had lesions involving the corpus callosum. The distribution of SWI lesions was similar to that seen in patients with hypoxic respiratory failure, sepsis, and disseminated intravascular coagulation. Brain autopsy in one patient revealed that SWI lesions corresponded to widespread microvascular injury, characterized by perivascular and parenchymal petechial hemorrhages and microscopic ischemic lesions. Collectively, these radiologic and histopathologic findings add to growing evidence that patients with severe COVID-19 are at risk for multifocal microvascular hemorrhagic and ischemic lesions in the subcortical and deep white matter.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Severity of Illness Index / Brain Injuries / Magnetic Resonance Imaging / Microvessels / COVID-19 Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Humans / Male / Middle aged Language: English Journal: J Neurol Sci Year: 2021 Document Type: Article Affiliation country: J.jns.2021.117308

Full text: Available Collection: International databases Database: MEDLINE Main subject: Severity of Illness Index / Brain Injuries / Magnetic Resonance Imaging / Microvessels / COVID-19 Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Humans / Male / Middle aged Language: English Journal: J Neurol Sci Year: 2021 Document Type: Article Affiliation country: J.jns.2021.117308