When PARPs Meet Antiviral Innate Immunity.
Trends Microbiol
; 29(9): 776-778, 2021 09.
Article
in English
| MEDLINE | ID: covidwho-1034111
ABSTRACT
The poly(ADP-ribose) polymerases (PARPs) family contains 17 members in humans, sharing a PARP domain to transfer ADP-ribose groups to target proteins to trigger ADP-ribosylation. The roles of PARPs have evolved from DNA damage repair to diverse biological processes, such as gene transcription, cellular stress response, etc. Recently, seminal studies have demonstrated the critical roles of PAPRs in antiviral innate immunity. PARPs catalyze ADP-ribosylation, a fundamental post-translational modification, using NAD+ as a substrate. ADP-ribosylation can occur either as mono- or poly-(ADP-ribosyl)ation, which is initially linked to DNA damage repair, as exemplified by PARP1. Recent advances in host antiviral immunity demonstrated that several PARPs, such as PARP9, 11, 12, 13, 14, etc., have broad-spectrum antiviral activities that are independent of their ADP-ribosylation.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Virus Diseases
/
Poly(ADP-ribose) Polymerases
Type of study:
Experimental Studies
/
Randomized controlled trials
Limits:
Animals
/
Humans
Language:
English
Journal:
Trends Microbiol
Journal subject:
Microbiology
Year:
2021
Document Type:
Article
Affiliation country:
J.tim.2021.01.002
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