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The Spectrum of Gastrointestinal Symptoms in Patients With Coronavirus Disease-19: Predictors, Relationship With Disease Severity, and Outcome.
Ghoshal, Uday C; Ghoshal, Ujjala; Mathur, Akash; Singh, Ratender K; Nath, Alok; Garg, Atul; Singh, Dharamveer; Singh, Sanjay; Singh, Jasmeet; Pandey, Ankita; Rai, Sushmita; Vasanth, Shruthi; Dhiman, Radha Krishan.
  • Ghoshal UC; Departments of Gastroenterology.
  • Ghoshal U; Microbiology.
  • Mathur A; Departments of Gastroenterology.
  • Singh RK; Emergency Medicine.
  • Nath A; Pulmonary Medicine.
  • Garg A; Microbiology.
  • Singh D; Microbiology.
  • Singh S; Microbiology.
  • Singh J; Microbiology.
  • Pandey A; Microbiology.
  • Rai S; Departments of Gastroenterology.
  • Vasanth S; Microbiology.
  • Dhiman RK; Director, Sanjay Gandhi Postgraduate Institute of Medical Science, Lucknow, India.
Clin Transl Gastroenterol ; 11(12): e00259, 2020 12.
Article in English | MEDLINE | ID: covidwho-1034415
ABSTRACT

INTRODUCTION:

We prospectively studied the frequency, spectrum, and predictors of gastrointestinal (GI) symptoms among patients with coronavirus disease-19 (COVID-19) and the relationship between GI symptoms and the severity and outcome.

METHODS:

Consecutive patients with COVID-19, diagnosed in a university hospital referral laboratory in northern India, were evaluated for clinical manifestations including GI symptoms, their predictors, and the relationship between the presence of these symptoms, disease severity, and outcome on univariate and multivariate analyses.

RESULTS:

Of 16,317 subjects tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in their oropharyngeal and nasopharyngeal swabs during April-May 2020, 252 (1.5%) were positive. Of them, 208 (82.5%) were asymptomatic; of the 44 symptomatic patients, 18 (40.9%) had non-GI symptoms, 15 (34.1%) had a combination of GI and non-GI symptoms, and 11 (25.0%) had GI symptoms only. Thirty-three had mild-to-moderate disease, 8 severe, and 5 critical. Five patients (1.98%) died. On multivariate analysis, the factors associated with the presence of GI symptoms included the absence of contact history and presence of non-GI symptoms and comorbid illnesses. Patients with GI synptoms more often had severe, critical illness and fatal outcome than those without GI symptoms.

DISCUSSION:

Eighty-two percent of patients with COVID-19 were asymptomatic, and 10.3% had GI symptoms; severe and fatal disease occurred only in 5% and 2%, respectively. The presence of GI symptoms was associated with a severe illness and fatal outcome on multivariate analysis. Independent predictors of GI symptoms included the absence of contact history, presence of non-GI symptoms, and comorbid illnesses.(Equation is included in full-text article.).
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Gastrointestinal Diseases / COVID-19 Testing / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: Clin Transl Gastroenterol Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Gastrointestinal Diseases / COVID-19 Testing / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: Clin Transl Gastroenterol Year: 2020 Document Type: Article