Post-COVID-19 Cholangiopathy: A Novel Entity.
Am J Gastroenterol
; 116(5): 1077-1082, 2021 05 01.
Article
in English
| MEDLINE | ID: covidwho-1034416
ABSTRACT
INTRODUCTION:
Liver chemistry abnormalities are a frequent manifestation of coronavirus disease 2019 (COVID-19) but are usually transient and resolve with disease resolution.METHODS:
We describe the clinical course and histologic features of 3 adults who developed prolonged and severe cholestasis during recovery from critical cardiopulmonary COVID-19.RESULTS:
These patients had clinical and histologic features similar to secondary sclerosing cholangitis of the critically ill patient, but with unique histologic features including severe cholangiocyte injury and intrahepatic microangiopathy suggestive of direct hepatic injury from COVID-19.DISCUSSION:
We believe that these cases constitute a novel severe post-COVID-19 cholangiopathy with potential for long-term hepatic morbidity.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Cholangitis
/
COVID-19
/
Liver
/
Liver Function Tests
Type of study:
Case report
/
Diagnostic study
/
Prognostic study
Topics:
Long Covid
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Am J Gastroenterol
Year:
2021
Document Type:
Article
Affiliation country:
Ajg.0000000000001154
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