Glucose-6-phosphate dehydrogenase deficiency enhances Covid-19 infection in elderly people.
Bratisl Lek Listy
; 121(11): 786-788, 2020.
Article
in English
| MEDLINE | ID: covidwho-1034641
ABSTRACT
Our understanding of the mechanisms responsible for death of aged people from Covid-19 became one of the major concerns of these days. Glucose-6-phosphate dehydrogenase (G6PD) enhances the normal senescence and accelerates the precocious removal of chronologically young, yet biologically aged cells. Thus, its deficiency is associated with an increase in the cellular oxidative stress. Accumulating evidence showed that oxidative stress has a fundamental role in several age-related diseases. Nowadays, Covid-19 is considered a serious health problem worldwide. The host cellular environment is the key determinant of pathogen Infectivity. Most respiratory viral infections have a strong association with Glucose-6-phosphate dehydrogenase. Unfortunately, this enzyme deficiency markedly decreases with aging what is involved in increasing of the morbidity rate. The aim of this mini review was to shed more light on the role of G6PD deficiency in aged people infected with Covid-19 (Ref. 20). Keywords GSPD, Covid-19, elderly people.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Coronavirus Infections
/
Glucosephosphate Dehydrogenase Deficiency
Type of study:
Observational study
Limits:
Aged
/
Humans
Language:
English
Journal:
Bratisl Lek Listy
Year:
2020
Document Type:
Article
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