Mass spectrometry reveals potential of ß-lactams as SARS-CoV-2 Mpro inhibitors.
Chem Commun (Camb)
; 57(12): 1430-1433, 2021 Feb 15.
Article
in English
| MEDLINE | ID: covidwho-1387498
ABSTRACT
The main viral protease (Mpro) of SARS-CoV-2 is a nucleophilic cysteine hydrolase and a current target for anti-viral chemotherapy. We describe a high-throughput solid phase extraction coupled to mass spectrometry Mpro assay. The results reveal some ß-lactams, including penicillin esters, are active site reacting Mpro inhibitors, thus highlighting the potential of acylating agents for Mpro inhibition.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Protease Inhibitors
/
Mass Spectrometry
/
Cysteine Endopeptidases
/
Beta-Lactams
/
SARS-CoV-2
Limits:
Humans
Language:
English
Journal:
Chem Commun (Camb)
Journal subject:
Chemistry
Year:
2021
Document Type:
Article
Affiliation country:
D0CC06870E
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