Your browser doesn't support javascript.
Altered Cholesterol and Lipid Synthesis Mediates Hyperinflammation in COVID-19.
Sohrabi, Yahya; Reinecke, Holger; Godfrey, Rinesh.
  • Sohrabi Y; Department of Cardiology I - Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, Münster, Germany; Institutes of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia. Electronic address: yahya.sohrabi@ukmuenster.de.
  • Reinecke H; Department of Cardiology I - Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, Münster, Germany.
  • Godfrey R; Department of Cardiology I - Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, Münster, Germany.
Trends Endocrinol Metab ; 32(3): 132-134, 2021 03.
Article in English | MEDLINE | ID: covidwho-1036177
ABSTRACT
Recent data have revealed that fructose-rich diet triggers inflammation and lipid synthesis. Furthermore, lipid metabolism, cholesterol synthesis and sterol regulatory element binding protein-2 (SREBP-2) activation correlates with coronavirus disease 2019 (COVID-19)-induced cytokine storm. High fructose consumption result in SREBPs activation, altered cholesterol and lipid synthesis and may establish an innate immune memory in the cells, leading to severe COVID-19 in patients with obesity.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Lipogenesis / COVID-19 Limits: Humans Language: English Journal: Trends Endocrinol Metab Journal subject: Endocrinology / Metabolism Year: 2021 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Lipogenesis / COVID-19 Limits: Humans Language: English Journal: Trends Endocrinol Metab Journal subject: Endocrinology / Metabolism Year: 2021 Document Type: Article