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Development of SARS-CoV-2 IgM and IgG antibodies in a relapsing multiple sclerosis patient on ofatumumab.
Flores-Gonzalez, Ramon E; Hernandez, Jeffrey; Tornes, Leticia; Rammohan, Kottil; Delgado, Silvia.
  • Flores-Gonzalez RE; Department of Neurology, MS Division, University of Miami Miller School of Medicine, 1120 NW 14 Street, Suite 1323, Miami, FL, 33136, USA.
  • Hernandez J; Department of Neurology, MS Division, University of Miami Miller School of Medicine, 1120 NW 14 Street, Suite 1323, Miami, FL, 33136, USA.
  • Tornes L; Department of Neurology, MS Division, University of Miami Miller School of Medicine, 1120 NW 14 Street, Suite 1323, Miami, FL, 33136, USA.
  • Rammohan K; Department of Neurology, MS Division, University of Miami Miller School of Medicine, 1120 NW 14 Street, Suite 1323, Miami, FL, 33136, USA.
  • Delgado S; Department of Neurology, MS Division, University of Miami Miller School of Medicine, 1120 NW 14 Street, Suite 1323, Miami, FL, 33136, USA. Electronic address: Sdelgado1@med.miami.edu.
Mult Scler Relat Disord ; 49: 102777, 2021 Apr.
Article in English | MEDLINE | ID: covidwho-1036334
Semantic information from SemMedBD (by NLM)
1. immunoglobulin G TREATS Multiple Sclerosis
Subject
immunoglobulin G
Predicate
TREATS
Object
Multiple Sclerosis
2. Multiple Sclerosis PROCESS_OF Patients
Subject
Multiple Sclerosis
Predicate
PROCESS_OF
Object
Patients
3. immunoglobulin G TREATS Patients
Subject
immunoglobulin G
Predicate
TREATS
Object
Patients
4. SARS-CoV-2 IgM|CD40LG TREATS Patients
Subject
SARS-CoV-2 IgM|CD40LG
Predicate
TREATS
Object
Patients
5. ofatumumab TREATS Patients
Subject
ofatumumab
Predicate
TREATS
Object
Patients
6. immunoglobulin G TREATS Multiple Sclerosis
Subject
immunoglobulin G
Predicate
TREATS
Object
Multiple Sclerosis
7. Multiple Sclerosis PROCESS_OF Patients
Subject
Multiple Sclerosis
Predicate
PROCESS_OF
Object
Patients
8. immunoglobulin G TREATS Patients
Subject
immunoglobulin G
Predicate
TREATS
Object
Patients
9. SARS-CoV-2 IgM|CD40LG TREATS Patients
Subject
SARS-CoV-2 IgM|CD40LG
Predicate
TREATS
Object
Patients
10. ofatumumab TREATS Patients
Subject
ofatumumab
Predicate
TREATS
Object
Patients
ABSTRACT
We report the case of a MS patient on subcutaneous ofatumumab who became infected with SARS-CoV-2 and remained asymptomatic while developing antiviral IgM and IgG antibodies. The patient was B-cell depleted with normal serum immunoglobulin levels. Anti-SARS-CoV-2 IgG antibodies remained positive three months after the initial infection. These findings suggest that a MS patient treated with ofatumumab may be able to mount an effective humoral response to SARS-CoV-2 infection and probably to COVID-19 vaccines as well. Further research will be necessary to evaluate the humoral response of MS patients on ofatumumab to SARS-CoV-2 infection and COVID-19 vaccines.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Antibodies, Monoclonal, Humanized / COVID-19 / Antibodies, Viral / Multiple Sclerosis Type of study: Case report Topics: Vaccines Limits: Humans Language: English Journal: Mult Scler Relat Disord Year: 2021 Document Type: Article Affiliation country: J.msard.2021.102777

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antibodies, Monoclonal, Humanized / COVID-19 / Antibodies, Viral / Multiple Sclerosis Type of study: Case report Topics: Vaccines Limits: Humans Language: English Journal: Mult Scler Relat Disord Year: 2021 Document Type: Article Affiliation country: J.msard.2021.102777