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Identification of similar epitopes between severe acute respiratory syndrome coronavirus-2 and Bacillus Calmette-Guérin: potential for cross-reactive adaptive immunity.
Urbán, Szabolcs; Paragi, Gábor; Burián, Katalin; McLean, Gary R; Virok, Dezso P.
  • Urbán S; Department of Nuclear Medicine University of Szeged Szeged Hungary.
  • Paragi G; MTA-SZTE Biomimetic Systems Research Group University of Szeged Szeged Hungary.
  • Burián K; Institute of Physics University of Pecs Pecs Hungary.
  • McLean GR; Department of Medical Microbiology and Immunobiology University of Szeged Szeged Hungary.
  • Virok DP; Cellular and Molecular Immunology Research Centre London Metropolitan University London UK.
Clin Transl Immunology ; 9(12): e1227, 2020.
Article in English | MEDLINE | ID: covidwho-1037499
ABSTRACT

OBJECTIVES:

Bacillus Calmette-Guérin (BCG) vaccination has been implicated in protection against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and as a non-specific immunisation method against the virus. We therefore decided to investigate T-cell and B-cell epitopes within the BCG-Pasteur strain proteome for similarity to immunogenic peptides of SARS-CoV-2.

METHODS:

We used NetMHC 4.0 and BepiPred 2.0 epitope prediction methods for the analysis of the BCG-Pasteur proteome to identify similar peptides to established and novel SARS-CoV-2 T-cell and B-cell epitopes.

RESULTS:

We found 112 BCG MHC-I-restricted T-cell epitopes similar to MHC-I-restricted T-cell SARS-CoV-2 epitopes and 690 BCG B-cell epitopes similar to SARS-CoV-2 B-cell epitopes. The SARS-CoV-2 T-cell epitopes represented 16 SARS-CoV-2 proteins, and the SARS-CoV-2 B-cell epitopes represented 5 SARS-CoV-2 proteins, including the receptor binding domain of the spike glycoprotein.

CONCLUSION:

Altogether, our results provide a mechanistic basis for the potential cross-reactive adaptive immunity that may exist between the two microorganisms.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study / Randomized controlled trials Topics: Vaccines Language: English Journal: Clin Transl Immunology Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study / Randomized controlled trials Topics: Vaccines Language: English Journal: Clin Transl Immunology Year: 2020 Document Type: Article