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Treatment Adherence and Clinical Outcomes of Patients with Inflammatory Bowel Disease on Biological Agents During the SARS-CoV-2 Pandemic.
Iborra, Ignacio; Puig, Maria; Marín, Laura; Calafat, Margalida; Cañete, Fiorella; Quiñones, Carles; González-González, Laura; Cardona, Glòria; Mañosa, Míriam; Domènech, Eugeni.
  • Iborra I; Gastroenterology Department, Hospital Universitari Germans Trias i Pujol, Carretera del Canyet s/n, 08916, Badalona, Catalonia, Spain.
  • Puig M; Gastroenterology Department, Hospital Universitari Germans Trias i Pujol, Carretera del Canyet s/n, 08916, Badalona, Catalonia, Spain.
  • Marín L; Gastroenterology Department, Hospital Universitari Germans Trias i Pujol, Carretera del Canyet s/n, 08916, Badalona, Catalonia, Spain.
  • Calafat M; Gastroenterology Department, Hospital Universitari Germans Trias i Pujol, Carretera del Canyet s/n, 08916, Badalona, Catalonia, Spain.
  • Cañete F; Centro de Investigación Biomédica en red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Catalonia, Spain.
  • Quiñones C; Gastroenterology Department, Hospital Universitari Germans Trias i Pujol, Carretera del Canyet s/n, 08916, Badalona, Catalonia, Spain.
  • González-González L; Centro de Investigación Biomédica en red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Catalonia, Spain.
  • Cardona G; Pharmacy Department, Hospital Universitari Germans Trias i Pujol, Badalona, Catalonia, Spain.
  • Mañosa M; Gastroenterology Department, Hospital Universitari Germans Trias i Pujol, Carretera del Canyet s/n, 08916, Badalona, Catalonia, Spain.
  • Domènech E; Pharmacy Department, Hospital Universitari Germans Trias i Pujol, Badalona, Catalonia, Spain.
Dig Dis Sci ; 66(12): 4191-4196, 2021 12.
Article in English | MEDLINE | ID: covidwho-1037968
ABSTRACT

BACKGROUND:

The outbreak of COVID19 evolved rapidly into a global pandemic, forcing hospitals, including inflammatory bowel disease (IBD) referral units, to change their practices to ensure quality of care.

AIMS:

To describe the clinical outcomes and the fulfilment of the treatment schedule of patients with IBD treated with biological agents in a single-center of a red-zone of the pandemic, and to report the patients' perceptions about COVID-19 and the measures adopted at our center.

METHODS:

Therapeutic adherence and clinical outcomes were collected for all patients undergoing treatment with intravenous biologicals and subcutaneous biologicals at our center. A telephone survey was also performed to assess these patients' perceptions of the COVID pandemic and the related measures adopted at their IBD unit.

RESULTS:

A total of 234 patients were included (117 on intravenous and 117 on subcutaneous biologicals). Only 10% of patients postponed intravenous infusions intentionally and 5% postponed the collection of subcutaneous biologicals at the hospital pharmacy. Only five confirmed COVID-19 cases were registered (2.1%), all of them of mild severity. One hundred and fifty-five patients participated in the survey (77 on intravenous and 78 on subcutaneous drugs). Fear of going to the hospital was the most common reason for postponing biological administrations. Among those on combination therapy, only 7% admitted to have withdrawn immunosuppressants.

CONCLUSIONS:

Adherence to intravenous and subcutaneous biological therapies during the pandemic was high in a single-center cohort of IBD patients even though the cumulative incidence of confirmed COVID-19 was low.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Biological Products / Colitis, Ulcerative / Crohn Disease / Delivery of Health Care, Integrated / Medication Adherence / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Female / Humans / Male Language: English Journal: Dig Dis Sci Year: 2021 Document Type: Article Affiliation country: S10620-020-06807-0

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Biological Products / Colitis, Ulcerative / Crohn Disease / Delivery of Health Care, Integrated / Medication Adherence / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Female / Humans / Male Language: English Journal: Dig Dis Sci Year: 2021 Document Type: Article Affiliation country: S10620-020-06807-0