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The Immunopathological and Histological Landscape of COVID-19-Mediated Lung Injury.
Zarrilli, Giovanni; Angerilli, Valentina; Businello, Gianluca; Sbaraglia, Marta; Traverso, Giulia; Fortarezza, Francesco; Rizzo, Stefania; De Gaspari, Monica; Basso, Cristina; Calabrese, Fiorella; Dei Tos, Angelo Paolo; Fassan, Matteo.
  • Zarrilli G; Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, 35121 Padua, Italy.
  • Angerilli V; Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, 35121 Padua, Italy.
  • Businello G; Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, 35121 Padua, Italy.
  • Sbaraglia M; Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, 35121 Padua, Italy.
  • Traverso G; Istituto Oncologico Veneto, IOV-IRCCS, 35128 Padua, Italy.
  • Fortarezza F; Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35121 Padua, Italy.
  • Rizzo S; Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35121 Padua, Italy.
  • De Gaspari M; Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35121 Padua, Italy.
  • Basso C; Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35121 Padua, Italy.
  • Calabrese F; Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35121 Padua, Italy.
  • Dei Tos AP; Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, 35121 Padua, Italy.
  • Fassan M; Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, 35121 Padua, Italy.
Int J Mol Sci ; 22(2)2021 01 19.
Article in English | MEDLINE | ID: covidwho-1038653
ABSTRACT
A complete understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) physiopathology and related histopathologic lesions is necessary to improve treatment and outcome of coronavirus disease 2019 (COVID-19) patients. Many studies have focused on autopsy findings in COVID-19-related deaths to try and define any possible specific pattern. Histopathologic alterations are principally found within lungs and blood vessels, and these abnormalities also seem to have the highest clinical impact. Nevertheless, many of the morphological data collected so far are non-specific, fickle, and possibly associated with other co-existing factors. The aim of this minireview is to describe the main histopathological features related to COVID-19 and the mechanism known as "cytokine storm".
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Lung Injury / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijms22020974

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Lung Injury / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijms22020974