The potential association between PARP14 and SARS-CoV-2 infection (COVID-19).
Future Med Chem
; 13(6): 587-592, 2021 03.
Article
in English
| MEDLINE | ID: covidwho-1038712
ABSTRACT
Understanding the potential association between the poly (ADP-ribose) polymerase member 14 (PARP14) and the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may aid in understanding the host immunopathological response to the virus. PARP14 has an emerging role in viral infections, and this article considers its potential mechanisms for action in either a pro- or anti-viral manner. It is evident that more experimental work is required; however, PARP14 appears vital in controlling the interferon response to the SARS-CoV-2 infection and has potential roles in balancing the proinflammatory cytokines of the cytokine storm. Furthermore, the SARS-CoV-2 macrodomain can prevent the PARP14-mediated antiviral response, suggesting a more complex relationship between PARP14 activity and SARS-CoV-2 infections.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Poly(ADP-ribose) Polymerases
/
SARS-CoV-2
/
COVID-19
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Future Med Chem
Year:
2021
Document Type:
Article
Affiliation country:
Fmc-2020-0226
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