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Bioinspired Spiky Peroxidase-Mimics for Localized Bacterial Capture and Synergistic Catalytic Sterilization.
Yang, Ye; Wu, Xizheng; Ma, Lang; He, Chao; Cao, Sujiao; Long, Yanping; Huang, Jianbo; Rodriguez, Raul D; Cheng, Chong; Zhao, Changsheng; Qiu, Li.
  • Yang Y; College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Department of Ultrasound, West China Hospital, Sichuan University, Chengdu, 610065, China.
  • Wu X; College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Department of Ultrasound, West China Hospital, Sichuan University, Chengdu, 610065, China.
  • Ma L; College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Department of Ultrasound, West China Hospital, Sichuan University, Chengdu, 610065, China.
  • He C; College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Department of Ultrasound, West China Hospital, Sichuan University, Chengdu, 610065, China.
  • Cao S; College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Department of Ultrasound, West China Hospital, Sichuan University, Chengdu, 610065, China.
  • Long Y; College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Department of Ultrasound, West China Hospital, Sichuan University, Chengdu, 610065, China.
  • Huang J; College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Department of Ultrasound, West China Hospital, Sichuan University, Chengdu, 610065, China.
  • Rodriguez RD; Tomsk Polytechnic University, Lenina ave. 30, Tomsk, 634034, Russia.
  • Cheng C; College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Department of Ultrasound, West China Hospital, Sichuan University, Chengdu, 610065, China.
  • Zhao C; Department of Chemistry and Biochemistry, Freie Universität Berlin, Takustrasse 3, 14195, Berlin, Germany.
  • Qiu L; College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Department of Ultrasound, West China Hospital, Sichuan University, Chengdu, 610065, China.
Adv Mater ; 33(8): e2005477, 2021 Feb.
Article in English | MEDLINE | ID: covidwho-1039151
ABSTRACT
Besides the pandemic caused by the coronavirus outbreak, many other pathogenic microbes also pose a devastating threat to human health, for instance, pathogenic bacteria. Due to the lack of broad-spectrum antibiotics, it is urgent to develop nonantibiotic strategies to fight bacteria. Herein, inspired by the localized "capture and killing" action of bacteriophages, a virus-like peroxidase-mimic (V-POD-M) is synthesized for efficient bacterial capture (mesoporous spiky structures) and synergistic catalytic sterilization (metal-organic-framework-derived catalytic core). Experimental and theoretical calculations show that the active compound, MoO3 , can serve as a peroxo-complex-intermediate to reduce the free energy for catalyzing H2 O2 , which mainly benefits the generation of •OH radicals. The unique virus-like spikes endow the V-POD-M with fast bacterial capture and killing abilities (nearly 100% at 16 µg mL-1 ). Furthermore, the in vivo experiments show that V-POD-M possesses similar disinfection treatment and wound skin recovery efficiencies to vancomycin. It is suggested that this inexpensive, durable, and highly reactive oxygen species (ROS) catalytic active V-POD-M provides a promising broad-spectrum therapy for nonantibiotic disinfection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Oxides / Peroxidase / Biomimetic Materials / Anti-Bacterial Agents Limits: Humans Language: English Journal: Adv Mater Journal subject: Biophysics / Chemistry Year: 2021 Document Type: Article Affiliation country: Adma.202005477

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Oxides / Peroxidase / Biomimetic Materials / Anti-Bacterial Agents Limits: Humans Language: English Journal: Adv Mater Journal subject: Biophysics / Chemistry Year: 2021 Document Type: Article Affiliation country: Adma.202005477