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Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients.
Tan, Anthony T; Linster, Martin; Tan, Chee Wah; Le Bert, Nina; Chia, Wan Ni; Kunasegaran, Kamini; Zhuang, Yan; Tham, Christine Y L; Chia, Adeline; Smith, Gavin J D; Young, Barnaby; Kalimuddin, Shirin; Low, Jenny G H; Lye, David; Wang, Lin-Fa; Bertoletti, Antonio.
  • Tan AT; Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore, Singapore.
  • Linster M; Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore, Singapore.
  • Tan CW; Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore, Singapore.
  • Le Bert N; Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore, Singapore.
  • Chia WN; Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore, Singapore.
  • Kunasegaran K; Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore, Singapore.
  • Zhuang Y; Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore, Singapore.
  • Tham CYL; Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore, Singapore.
  • Chia A; Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore, Singapore.
  • Smith GJD; Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore, Singapore.
  • Young B; National Centre for Infectious Diseases, Singapore, Singapore; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore; Lee Kong Cian School of Medicine, Singapore, Singapore.
  • Kalimuddin S; Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore, Singapore; Department of Infectious Diseases, Singapore General Hospital, Singapore, Singapore.
  • Low JGH; Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore, Singapore; Department of Infectious Diseases, Singapore General Hospital, Singapore, Singapore.
  • Lye D; National Centre for Infectious Diseases, Singapore, Singapore; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore; Lee Kong Cian School of Medicine, Singapore, Singapore; Yong Loo Lin School of Medicine, National University Singapore, Singapore, Singapore.
  • Wang LF; Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore, Singapore.
  • Bertoletti A; Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore, Singapore; Singapore Immunology Network, A(∗)STAR, Singapore, Singapore. Electronic address: antonio@duke-nus.edu.sg.
Cell Rep ; 34(6): 108728, 2021 02 09.
Article in English | MEDLINE | ID: covidwho-1039309
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
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ABSTRACT
Virus-specific humoral and cellular immunity act synergistically to protect the host from viral infection. We interrogate the dynamic changes of virological and immunological parameters in 12 patients with symptomatic acute SARS-CoV-2 infection from disease onset to convalescence or death. We quantify SARS-CoV-2 viral RNA in the respiratory tract in parallel with antibodies and circulating T cells specific for various structural (nucleoprotein [NP], membrane [M], ORF3a, and spike) and non-structural (ORF7/8, NSP7, and NSP13) proteins. Although rapid induction and quantity of humoral responses associate with an increase in disease severity, early induction of interferon (IFN)-γ-secreting SARS-CoV-2-specific T cells is present in patients with mild disease and accelerated viral clearance. These findings provide support for the prognostic value of early functional SARS-CoV-2-specific T cells with important implications in vaccine design and immune monitoring.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: T-Lymphocytes / Interferon-gamma / COVID-19 Type of study: Case report / Cohort study / Observational study / Prognostic study Topics: Vaccines Limits: Adult / Aged / Humans / Middle aged Language: English Journal: Cell Rep Year: 2021 Document Type: Article Affiliation country: J.celrep.2021.108728

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Full text: Available Collection: International databases Database: MEDLINE Main subject: T-Lymphocytes / Interferon-gamma / COVID-19 Type of study: Case report / Cohort study / Observational study / Prognostic study Topics: Vaccines Limits: Adult / Aged / Humans / Middle aged Language: English Journal: Cell Rep Year: 2021 Document Type: Article Affiliation country: J.celrep.2021.108728