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Blood omega-3 fatty acids and death from COVID-19: A pilot study.
Asher, Arash; Tintle, Nathan L; Myers, Michael; Lockshon, Laura; Bacareza, Heribert; Harris, William S.
  • Asher A; Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center, Los Angeles, CA.
  • Tintle NL; Fatty Acid Research Institute, Sioux Falls, SD; Department of Mathematics and Statistics, Dordt University, Sioux Center, IA.
  • Myers M; Los Alamitos Medical Center, Los Alamitos, CA.
  • Lockshon L; Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center, Los Angeles, CA.
  • Bacareza H; Department of Medical Affairs, Cedars-Sinai Medical Center, Los Angeles, CA.
  • Harris WS; Fatty Acid Research Institute, Sioux Falls, SD; Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD. Electronic address: wsh@faresinst.com.
Prostaglandins Leukot Essent Fatty Acids ; 166: 102250, 2021 03.
Article in English | MEDLINE | ID: covidwho-1039530
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ABSTRACT
Very-long chain omega-3 fatty acids (EPA and DHA) have anti-inflammatory properties that may help reduce morbidity and mortality from COVID-19 infection. We conducted a pilot study in 100 patients to test the hypothesis that RBC EPA+DHA levels (the Omega-3 Index, O3I) would be inversely associated with risk for death by analyzing the O3I in banked blood samples drawn at hospital admission. Fourteen patients died, one of 25 in quartile 4 (Q4) (O3I ≥5.7%) and 13 of 75 in Q1-3. After adjusting for age and sex, the odds ratio for death in patients with an O3I in Q4 vs Q1-3 was 0.25, p = 0.07. Although not meeting the classical criteria for statistical significance, this strong trend suggests that a relationship may indeed exist, but more well-powered studies are clearly needed.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Fatty Acids, Omega-3 / COVID-19 Type of study: Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Prostaglandins Leukot Essent Fatty Acids Journal subject: Endocrinology Year: 2021 Document Type: Article Affiliation country: J.plefa.2021.102250

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Fatty Acids, Omega-3 / COVID-19 Type of study: Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Prostaglandins Leukot Essent Fatty Acids Journal subject: Endocrinology Year: 2021 Document Type: Article Affiliation country: J.plefa.2021.102250