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D-dimer levels is associated with severe COVID-19 infections: A meta-analysis.
Du, Wei-Na; Zhang, Ying; Yu, Yong; Zhang, Ru-Min.
  • Du WN; Department of Critical Care Medicine, Huantai County People's Hospital, Zibo, China.
  • Zhang Y; Department of Critical Care Medicine, Zibo Central Hospital, Zibo, China.
  • Yu Y; Department of Critical Care Medicine, Zibo Central Hospital, Zibo, China.
  • Zhang RM; Department of Critical Care Medicine, Zibo Central Hospital, Zibo, China.
Int J Clin Pract ; 75(8): e14031, 2021 Aug.
Article in English | MEDLINE | ID: covidwho-1039826
ABSTRACT

OBJECTIVE:

The ongoing pandemic of COVID-19 caused by the novel coronavirus Syndrome-Coronavirus-2 (SARS-CoV-2) is an emerging, rapidly evolving situation. Excluded typical manifestation of pneumonia and acute respiratory symptoms, COVID-19 patients also have abnormal D-dimer concentration in the serum, but the results are controversial.

METHOD:

A meta-analysis first aims to explored the connection between D-dimer concentration and COVID-19 patients.

RESULTS:

Our results found a significant relationship between D-dimer and COVID-19, with a pooled OR of 1.90 (95% CI 1.32-2.48; P < .001). The pooled data were calculated with the REM as a high heterogeneity within the studies. The sensitivity analysis results showed that the WMD ranged from 1.69 (95% CI 1.15 to 2.23) to 2.06 (95% CI 1.51 to 2.62) and there was no publication bias.

CONCLUSIONS:

Our meta-analysis showed that the severity of patients with COVID-19 significance related to D-dimer concentrations. Meanwhile, the severe COVID-19 patients tend to have a higher concentration of D-dimer when compared with non-severe patients. REVIEW CRITERIA We used MASH word and searched the online database and followed the inclusion and exclusion standard. The detailed information can be found in the text. MESSAGE FOR THE CLINIC Our meta-analysis showed that the severity of patients with COVID-19 significance related to D-dimer concentrations. This may be helpful for the clinic COVID-19 patients.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: COVID-19 Subject: COVID-19 Type of study: Risk factors Language: English Journal: Int J Clin Pract Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: COVID-19 Subject: COVID-19 Type of study: Risk factors Language: English Journal: Int J Clin Pract Year: 2021
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